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Cat. No. Product Name Information
PC-35554

GSK4027

PCAF/GCN5 inhibitor

GSK4027 (GSK 4027, GSK-4027) is a potent, selective, cell-penetrant chemical probe inhibitor of PCAF/GCN5 bromodomain with pKi of 8.9 for both.
PC-35423

MS645

BRD4 inhibitor

MS645 (MS-645) is a novel, bivalent bromodomain (BRD) inhibitor with Ki of 18.4 nM for tandem BD1-BD2 (BRD4 BD1/BD2 ), shows12- to 28-fold gain in affinity for binding to the tandem BD1-BD2 over the single BD1 or BD2.
PC-35401

BET inhibitor CF53

BET inhibitor

BET inhibitor CF53 is a highly potent, orally active inhibitor of bromodomain and extra-terminal (BET) with Ki of <1 nM (BRD4 BD1).
PC-35400

QCA276

BET inhibitor

QCA276 is a novel potent BET proteins inhibitor with IC50/Ki of 10/.3 nM, QCA276 is the BET ligand for PROTAC QCA570.
PC-35172

ABBV-744

BET BD2 inhibitor

ABBV-744 (ABBV744) is a highly potent and selective inhibitor of the BD2 domain of BET family proteins with IC50 of 4-18 nM for BD2 of BRD2, BRD3, BRD4 and BRDT.
PC-35097

ZL0454

ZL0454 is a potent, highly selective small-molecule BRD4 inhibitor with IC50 of 49 and 32 nM for BRD4-BD1 and BRD4-BD2, respectively.
PC-35096

ZL0420

BRD4 inhibitor

ZL0420 (ZL-0420) is a potent, highly selective BRD4 inhibitor with IC50 of 27 and 32 nM for BRD4-BD1 and BRD4-BD2, respectively.
PC-63576

GSK8814

ATAD2/2B inhibitor

GSK8814 is a potent, selective inhibitor of ATAD2/2B bromodomain binding constant pKd of 8.1 in ITC assays.
PC-63543

CBP bromodomain inhibitor 17

CBP bromodomain inhibitor

CBP-IN-17 is a potent, selective CBP bromodomain inhibitor with IC50 of 69 nM, displays exquisite selectivity over BRD4(1) (IC50=18 uM) and the broader bromodomain family.
PC-63487

GSK-340

BET BD2 inhibitor

GSK-340 is a potent, selective inhibitor of second bromodomains of the BET family (BD2) with pKd of 8.18, 7.49, 7.72 and 7.68 for BRD4 BD2, BRD3 BD2, BRD2 BD2 and BRD4T BD2, respectively.
PC-63272

INCB057643

BET inhibitor

INCB057643 is a novel potent, selective, orally bioavailable BET inhibitor, reduces homologous recombination efficiency and augments PARP inhibitor activity in ovarian cancer.
PC-63255

SJ830599

SJ830599 is a modest selective BRD2-BD2 inhibitor with IC50 of 0.61 uM, 3.3-fold selectivity over BRD2-BD1.

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