| Cat. No. |
Product Name |
Information |
| PC-20119 |
Dual BRM and BRG1 inhibitor 12
SMARCA2/SMARCA4 inhibitor 12
|
Dual BRM and BRG1 inhibitor 12 (SMARCA2/SMARCA4 inhibitor 12) is a potent inhibitor of Brahma Homolog (BRM)/SMARCA2 and Brahma-related gene 1 (BRG1/SMARCA4) with IC50 of <5 nM for both. |
| PC-49860 |
FT-6876
CBP/p300 inhibitor
|
FT-6876 (FT 6876) is a potent, selective, orally active CBP/p300 bromodomains inhibitor with IC50 of 5/2 nM, respectively, >500-fold selectivity over BRD4 (IC50=2,320 nM) and other bromodomains. |
| PC-49600 |
YEATS4 binder 4d
YEATS4 inhibitor
|
YEATS4 binder 4d is a potent, selective small-molecule epigenetic reader YEATS4 binder with Ki of 33 nM, >10-fold selectivity over YEATS1, 2 and 3. |
| PC-49599 |
YEATS4 binder 4e
YEATS4 inhibitor
|
YEATS4 binder 4e is a potent, selective small-molecule epigenetic reader YEATS4 binder with Ki of 37 nM, >15-fold selectivity over YEATS1, 2 and 3. |
| PC-49467 |
I-BET432
Pan-BET inhibitor
|
I-BET432 is a potent, highly ligand-efficient, orally active pan-BET bromodomain inhibitor. |
| PC-49329 |
HP-4833
BET inhibitor
|
HPI-1 is a high affinity BET bromodomain binder with low nM Kd for BRD2/3/4 and about 10-fold lower affinity for BRDT. HPI-1 shows much higher affinity to BD2 of BRD2 (17 nM), than to BD1 (540 nM), no apparent selectivity between BRD2/3/4. |
| PC-49278 |
GSK761
SP140 inhibitor
|
GSK761 (GSK-761) is the first small molecule inhibitor of bromodomain-containing protein SP140, inhibits macrophage inflammatory function. |
| PC-49152 |
EA-89-YM35
BRD9 inhibitor
|
BRD9 inhibitor EA-89 is a potent and selective inhibitor that binds to BRD9 in a novel way. |
| PC-38761 |
BRD8 inhibitor DN01
BRD8 inhibitor
|
BRD8 inhibitor DN01 is a first-in-class selective and cellularly active probe for NuA4 factor BRD8 (BD1) with AlphaScreen IC50 of 12 nM, displays IC50 of 0.21 uM in-cell engagement within BRET displacement assays, shows no affinity for BRD8 (BD2), CBP, and p300. |
| PC-38620 |
BI 894999
BRD4 inhibitor
|
BI 894999 is a novel potent, selective BET inhibitor with IC50 of 5 and 41 nM for BRD4-BD1 and BRD4-BD2 bromodomains, respectively. |
| PC-73281 |
DC-CBi-22
CECR2 BRD inhibitor
|
DC-CBi-22 is a highly potent, selective CECR2 bromodomain inhibitor with IC50 of 8.0 nM, 24.9-fold selectivity over BPTF BRD. |
| PC-73224 |
XY153
BRD4 BD2 inhibitor
|
XY153 is a potent, BD2-selective BET inhibitor with IC50 of 0.79 nM for BRD4 BD2, 354-fold selectivity over BRD4 BD1. |
