| Cat. No. |
Product Name |
Information |
| PC-20657 |
Extracellular vesicle enhancer 634
Extracellular vesicle enhancer
|
Extracellular vesicle enhancer 634 (Compound 634) is a small molecule enhancer of extracellular vesicle (EV) release with immunostimulatory potency via induction of Ca2+ influx, which is mediated by store-operated Ca2+ entry (SOCE). |
| PC-20398 |
Rynaxypyr
RyR activator
|
Rynaxypyr is a highly potent and selective activator of insect ryanodine receptors (Hv RyR EC50=52 nM) with exceptional activity on a broad range of Lepidoptera. |
| PC-20397 |
RyR2 inhibitor EL9
RyR2 inhibitor
|
RyR2 inhibitor EL9 is a potent mutant RyR2 channel inhibitor, inhibits Ca2+ spark frequency (CaSF) in R176Q/+ myocytes with IC50 of 13 nM. |
| PC-20396 |
RyR2 inhibitor EL20
RyR2 inhibitor
|
RyR2 inhibitor EL20 is a potent antiarrhythmic compound, potently inhibits abnormal Ca2+ release in RyR2 R176Q myocytes with IC50 of 35.4 nM. |
| PC-20395 |
Cyantraniliprole
RyR activator
|
Cyantraniliprole (DPX-HGW86) is an insecticide of the ryanoid class, is a potent and selective anthranilic diamide ryanodine receptor (RyR) activator (Dipteran RyR, EC50=0.9 uM). |
| PC-20121 |
IPPQ
CaV2.2 inhibitor
|
IPPQ is a small molecule that selectively target the interface between the N-type calcium (CaV2.2) channel and CaVβ, specifically binds to CaVβ2a and inhibits CaVβ2's interaction with CaV.2-AID (alpha interacting domain). |
| PC-49733 |
PST3093
SERCA2a activator
|
PST3093 (PST 3093) is the main Istaroxime metabolite and a selective SERCA2a activator, reduces the SERCA2a KdCa value by about 20% at 100 nM. |
| PC-49732 |
Istaroxime hydrochloride
Na-K ATPase inhibitor
|
Istaroxime (PST2744) is an inotropic agent and Na(+)/K(+)-ATPase inhibitor, inhibits dog kidney Na(+)/K(+)-ATPase with IC50 of 0.43 uM, also stimulates SERCA2a. |
| PC-38654 |
CRAC inhibitor 36
CRAC channel inhibitor
|
CRAC inhibitor 36 is a novel potent, selective calcium release-activated calcium (CRAC) channels inhibitor with IC50 of 11 nM (IL-2 inhibition) and 243 nM (SOCE inhibition). |
| PC-38452 |
VK-II-36
RyR2 inhibitor
|
VK-II-36 is a carvedilol analogue that suppresses sarcoplasmic reticulum (SR) Ca(2+) release and does not block the β-receptor, via direct action on the cardiac ryanodine receptor type 2 (RyR2). |
| PC-72884 |
USP5-Cav3.2 inhibitor II-1
USP5-Cav3.2 inhibitor
|
USP5-Cav3.2 inhibitor II-1 is a small molecule inhibitor of USP5-Cav3.2 interaction, without affecting the enzymatic activity of USP5. |
| PC-36028 |
SAK3
|
SAK3 (T-VGCC enhancer SAK3) is a potent, orally acitve enhancer of T-type voltage-gated Ca2+ channel (T-VGCC), enhances CaV3.1 and CaV3.3, but not CaV3.2 activity at concentrations of 0.01-10 nM in neuro2A cells in vitro. |
