| Cat. No. |
Product Name |
Information |
| PC-47042 |
K284
CHI3L1 inhibitor
|
K284 is a selective small molecule inhibitor of chitinase 3 like1 (CHI3L1) with strong binding affinity (Kd=-9.7 kcal·mol-1), inhibits lung metastasis by blocking IL-13Rα2-mediated JNK-AP-1 signals. |
| PC-38628 |
OATD-01
CHIT1 inhibitor
|
OATD-01 (GLPG4716) is a highly potent, orally active chitotriosidase (CHIT1) inhibitor with IC50 of 26 (hCHIT1) and 29 nM (mCHIT1), inhibits hAMCase and mAMCase with IC50 of 9.0 and 7.8 nM, respectively. |
| PC-72373 |
Wyeth-1
hAMCase inhibitor
|
Wyeth-1 (hAMCase inhibitor 1) is a potent, selective inhibitor of human acidic mammalian chitinase (hAMCase) with IC50 of 210 nM, 20-fold selectivity over hCHIT1. |
| PC-72372 |
OAT-1441
hAMCase inhibitor
|
OAT-1441 (OAT1441) is a potent, selective inhibitor of human acidic mammalian chitinase (hAMCase) with IC50 of 7 nM. |
| PC-62540 |
OAT-177
Chitinase inhibitor
|
OAT-177 is a potent, selective, orally active acidic mammalian chitinase (AMCase) inhibitor with IC50 of 14 and 19 nM against human and mouse AMCas, respectively, >150-fold selectivity over mCHIT1. |
| PC-62539 |
OAT-2068
mCHIT1 inhibitor
|
OAT-2068 is a potent, selective, orally bioavailable inhibitor of mouse chitotriosidase (mCHIT1) with IC50 of 29 nM, 143-fold selectivity over mAMCase. |
| PC-21914 |
CHI3L1 inhibitor 30
CHI3L1 inhibitor
|
CHI3L1 inhibitor 30 is a potent, selective chitinase-3-like-1 (CHI3L1, YKL-40) inhibitor with IC50 of 50 nM, with little to no activity against hCHIT1 and hAMCase (IC50=6500 and 964 nM). |
| PC-21913 |
OAT-870
Chitinase inhibitor
|
OAT-870 is a potent dual AMCase and CHIT1 inhibitor with IC50 of 48/74 nM (human/ mouse CHIT1) and 22/30 nM (h/mAMCase). |
