| Cat. No. |
Product Name |
Information |
| PC-24482 |
LA-CB1
CDK4/6 degrader
|
LA-CB1 is a novel Abemaciclib derivative that induces CDK4/6 degradation through the ubiquitin-proteasome pathway, exerts robust anti-proliferative effects across a wide spectrum of cancer cell lines (A498 cell, IC50=0.21 uM). |
| PC-24325 |
SNX631-6
CDK8/19 inhibitor
|
SNX631-6 is an equipotent analog of SNX631 and potent, selective inhibitor of CDK8 and CDK19 with Kd values of 0.25 and 0.3 nM respectively. |
| PC-24231 |
YJZ5118
CDK12/13 inhibitor
|
YJZ5118 is a potent, highly selective covalent inhibitor of CDK12/13 with IC50 of 39.5/26.4 nM, respectively, demonstrates high selectivity over other CDKs. |
| PC-24198 |
Zeltociclib
CDK7 inhibitor
|
Zeltociclib is a potent, specific CDK7 inhibitor. |
| PC-24041 |
F059-1017
CDK8 inhibitor
|
F059-1017 is a potent, selective CDK8 inhibitor with IC50 of 558.1 nM, reduces phosphorylation and expression of signaling mediators associated with inflammation. |
| PC-23981 |
Arcyriaflavin A
CDK4 inhibitor
|
Arcyriaflavin A is a potent inhibitor of the cyclin D1/CDK4 complex with IC50 of 140 nM, also inhibits CaMKII with IC50 of 25 nM, suppresses tumor growth, migration, and invasion of metastatic melanoma cells. |
| PC-23770 |
E966-0530-45418
CDK8 inhibitor
|
E966-0530-45418 is a potent, selective inhibitor of CDK8 with IC50 of 129 nM, shows slightly weaker activity against CDK19 and does not inhibit other CDKs. |
| PC-23694 |
P162-0948
CDK8 inhibitor
|
P162-0948 is a potent, selective cyclin-dependent kinase 8 (CDK8) inhibitor with IC50 of 50.4 nM, disrupts TGF-β1-induced cell migration. |
| PC-23612 |
KY-065
CDK8 inhibitor
|
KY-065 is a potent, selective and ATP-competitive CDK8/19 inhibitor with IC50 of 4.4/3.6 nM respectively, without affecting the activities of other CDK family members. |
| PC-23502 |
BSJ-01-175
CDK12/13 inhibitor
|
BSJ-01-175 is a potent, selective dual CDK12/13 covalent inhibitor with IC50 of 156 nM (CDK12/CycK) and 282.6 nM（CDK3/CycK), targets cysteine Cys1039 on CDK12 (or Cys1017 on CDK13). |
| PC-23151 |
CDK-TCIP2
|
CDK-TCIP2 is a bivalent molecule linking CDK9 inhibitor SNS-032 to BCL6 ligand BI3812, activates BCL6-regulated transcription, potently and specifically kills BCL6-overexpressing cells with EC50 of 0.9 nM for SUDHL5 cells. |
| PC-23150 |
CDK-TCIP1
3008612-35-6
|
CDK-TCIP1 is a bivalent molecule linking CDK9 inhibitor SNS-032 to BCL6 ligand BI3812, potently and specifically kills BCL6-overexpressing cells with EC50 of 7.7 nM for SUDHL5 cells. |
