| Cat. No. |
Product Name |
Information |
| PC-45599 |
NU-2058
CDK1/2 inhibitor
|
NU-2058 is an ATP-competitive inhibitor of CDK1 and CDK2 with Ki of 5 uM and 12 uM respectively. |
| PC-43435 |
TAME
APC/C inhibitor
|
TAME (Tosyl-L-arginine methyl ester) is a small molecule anaphase-promoting complex/cyclosome (APC/C) inhibitor that binds to the APC preferentially suppresses APC/C(Cdc20) rather than APC/C(Cdh1). |
| PC-44628 |
Senexin A
CDK8/CDK19 inhibitor
|
Senexin A is a selective inhibitor of CDK8 (IC50=0.28 uM) and CDK19, inhibits CDK8 and CDK19 ATP site binding with Kd50 of 0.83 uM and 0.31 uM, respectively. |
| PC-45491 |
SU-9516
CDK2 inhibitor
|
SU-9516 is a potent, selective CDK2 inhibitor with IC50 of 22 nM. |
| PC-46009 |
THZ1 hydrochloride
CDK7 inhibitor
|
THZ1 hydrochloride is a potent, selective, covalent CDK7 inhibitor with IC50 of 3.2 nM. |
| PC-46008 |
THZ1
CDK7 inhibitor
|
THZ1 is a potent, selective, covalent CDK7 inhibitor with IC50 of 3.2 nM, also weakly inhibits CDK12 with IC50 of 250 nM. |
| PC-42578 |
PHA-848125
CDK/TRK inhibitor
|
Milciclib (PHA-848125) is a potent, selective, brain penetrant and orally available dual CDK and TRK inhibitor with IC50 of 45 and 53 nM for CDK2/cyclin A and TrkA, respectively. |
| PC-42067 |
R547
CDK inhibitor
|
R547 is a potent, selective and ATP-competitive CDK inhibitor with Ki of 1/3/1 nM for CDK1/2/4, respectively. |
| PC-45446 |
Purvalanol B
CDK inhibitor
|
Purvalanol B (NG-95) is a potent, cell-permeable, selective inhibitor of CDK with IC50s of 6, 6, 9, and 6 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, and cdk5-p35 respectively. |
| PC-45447 |
Purvalanol A
CDK inhibitor
|
Purvalanol A (NG-60) is a potent, cell-permeable, selective inhibitor of CDK with IC50s of 4, 70, 35, 850, and 75 nM for Cdc2/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk4/cyclin D1 and Cdk5-p35, respectively. |
| PC-42050 |
Flavopiridol hydrochloride
CDK inhibitor
|
Flavopiridol (Alvocidib) hydrochloride is a potent, ATP-competetive CDKs inhibitor with IC50 of 30, 170, 100 nM for CDk1, 2, 4, respectively. |
| PC-42049 |
Flavopiridol
CDK inhibitor
|
Flavopiridol (HMR-1275, Alvocidib) is a potent, ATP-competetive CDKs inhibitor with IC50 of 30, 170, 100 nM for CDk1, 2, 4, respectively. |
