| Cat. No. |
Product Name |
Information |
| PC-26376 |
CTX-439
CDK12 inhibitor
|
CTX-439 is a potent, selective, orally bioavailable, ATP-competitive CDK12/13 inhibitor with IC50 of 3.1/ 9.2 nM towards CDK12/Cyclin K and CDK13/Cyclin K, respectively, in cell-free assays. |
| PC-26363 |
Vustanaciclib
CDK2/4/6 inhibitor
|
Vustanaciclib (GDC-4198, RGT-419B) is a potent CDK2/4/6 inhibitor. |
| PC-25971 |
LL-K12-18
Cyclin K degrader
|
LL-K12-18 is a potent, dual-site molecular glue degrader of cyclin K with DC50 of 0.38 nM in MDA-MB-231 cells, inhibits CDK12 with IC50 of 283.9 nM. |
| PC-25672 |
LCI133
CDK4/6/9, AURKA/B inhibitor
|
LCI133 is a highly potent, selective multikinase CDK4/6/9 and AURKA/B inhibitor with IC50 of 4.7/10.2/4.1 nM for CDK4/6/9 and 2.8/10.6 nM for AURKA/B. |
| PC-25402 |
TP-1287
CDK9 inhibitor
|
TP-1287 is a prodrug of Alvocidib (Flavopiridol, HMR-1275), is an orally active CDK9 inhibitor. |
| PC-25358 |
CIRc-004
Cyclin A/B RxL inhibitor
|
CIRc-004 is a potent, cell-permeable dual cyclin A/B RxL inhibitor with IC50 of 0.13 and <0.02 uM for cyclin A1-CDK2 and cyclin B-CDK1, does not inhibit cyclin E1-CDK2, inhibits cyclin A/B-RxL interactions and induces apoptosis in cancer cells with high E2F activity. |
| PC-24989 |
AU3-14
CDK4/6 inhibitor
|
Auceliciclib (AU3-14, Ulecaciclib AU-314) is a potent and selective, brain-penetrant CDK4/6 inhibitor with Ki values ranging from 0.2 to 3.3 nM. |
| PC-24960 |
Mocaciclib
CDK7 inhibitor
|
Mocaciclib (Q901) is a highly selective and potent CDK7 inhibitor, forms a covalent bond with C312 of the CDK7 C-terminal domain. |
| PC-24915 |
AS3334366
CDK8/19 inhibitor, Foxp3 inducer
|
AS3334366 is a potent, selective orally active inhibitor of CDK8 and CDK19 with IC50 of 0.68 nM and 1.9 nM, respectively, AS3334366 is a potent Foxp3 inducer in Tconv cells with EC50 of 13.1 nM. |
| PC-24914 |
AS2863619
CDK8/19 inhibitor, Foxp3 inducer
|
AS2863619 is a potent, selective and orally active inhibitor of CDK8 and CDK19 with IC50 of 0.61 nM and 4.28 nM, respectively, AS2863619 is a potent Foxp3 inducer in Tconv cells with EC50 of 32.5 nM. |
| PC-24657 |
Bireociclib
CDK4/6 inhibitor
|
Bireociclib (XZP-3287) is a novel potent, selective cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitor with IC50 of 2.7/16 nM respectively. |
| PC-24530 |
Tagtociclib hydrate
CDK2 inhibitor
|
Tagtociclib hydrate (PF-07104091 hydrate, Tegtociclib hydrate) is a highly potent CDK2-selective inhibitor with Ki of 1.16 nM, shows potential for the treatment of cyclinE-amplified cancers. |
