Cat. No. |
Product Name |
Information |
PC-21053 |
HQ461
cyclin K degrader
|
HQ461 is a molecular glue promoting CDK12-DDB1 interaction to trigger cyclin K degradation, exhibits potent cytotoxicity to NSCLC cell line A549 with with IC50 of 1.3 uM. |
PC-20887 |
CDK2 inhibitor 5
CDK2 inhibitor
|
CDK2 inhibitor 5 is a potent, selective and allosteric CDK2 inhibitor with KD value of 18 nM, shows exquisite selectivity for CDK2 over CDK1. |
PC-20880 |
CAF-382
CDKL5 inhibitor
|
CAF-382 (CDKL5 inhibitor B1) is a potent, specific inhibitor of serine-threonine kinase cyclin dependent kinase-like 5 (CDKL5) with IC50 of 11 nM in NanoBRET assays, shows no activity against GSK3β. |
PC-20872 |
Ribociclib
CDK4/6 inhibitor
|
Ribociclib (LEE-011, LEE011) is a potent, highly selective, orally bioavailable CDK4/6 inhibitor with IC50 of 10/39 nM, respectively. |
PC-20691 |
NCGC00131308
IQGAP1-Cdc42 inhibitor
|
NCGC00131308 is a small molecule inhibitor that effectively disrupts IQGAP1-Cdc42 interaction in breast cancer cells, shows EC50 of 4.47 uM in biochemical HTRF assays. |
PC-20589 |
Abemaciclib
CDK4/6 inhibitor
|
Abemaciclib (LY2835219) is a potent, selective and competitive ATP CDK4/6 inhibitor with Ki values of 0.6 and 2.4 nM for CDK4/cyclin D1 and CDK6/cyclin D1, respectively. |
PC-20566 |
Apcin-A
APC inhibitor
|
Apcin-A, an Apcin derivative, is an anaphase-promoting complex (APC) inhibitor, interacts strongly with Cdc20, and inhibits the ubiquitination of Cdc20 substrates. |
PC-20494 |
Cdk5i peptide
Cdk5/p25 inhibitor
|
Cdk5i peptide is a Cdk5-derived 12-amino acid long Cdk5-derived peptide that interferes with the Cdk5/p25 complex with Kd of 0.17 uM, 40-fold more strongly to either Cdk5 or Cdk2 alone. |
PC-20345 |
Cdc25A inhibitor 7h
|
Cdc25A inhibitor 7h is a specific small molecule Cdc25A inhibitor, inhibits Cdc25A phosphatase activity, blocks loss of mitochondrial activity, and inhibits caspase-3 activation caused by NGF deprivation and 6-OHDA. |
PC-20344 |
Cdc25A inhibitor 7g
|
Cdc25A inhibitor 7g is a specific small molecule Cdc25A inhibitor, inhibits Cdc25A phosphatase activity, blocks loss of mitochondrial activity, and inhibits caspase-3 activation caused by NGF deprivation and 6-OHDA. |
PC-20315 |
LGR6768
CDK7 inhibitor
|
LGR6768 is a potent, selective CDK7 inhibitor with IC50 of 20 nM, >12-fold selectivity over other CDKs. |
PC-20284 |
QR-6401
CDK2 inhibitor
|
QR-6401 (QR6401) is a highly potent, selective, oral macrocyclic CDK2 inhibitor. |