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Cat. No. Product Name Information
PC-21053

HQ461

cyclin K degrader

HQ461 is a molecular glue promoting CDK12-DDB1 interaction to trigger cyclin K degradation, exhibits potent cytotoxicity to NSCLC cell line A549 with with IC50 of 1.3 uM.
PC-20887

CDK2 inhibitor 5

CDK2 inhibitor

CDK2 inhibitor 5 is a potent, selective and allosteric CDK2 inhibitor with KD value of 18 nM, shows exquisite selectivity for CDK2 over CDK1.
PC-20880

CAF-382

CDKL5 inhibitor

CAF-382 (CDKL5 inhibitor B1) is a potent, specific inhibitor of serine-threonine kinase cyclin dependent kinase-like 5 (CDKL5) with IC50 of 11 nM in NanoBRET assays, shows no activity against GSK3β.
PC-20872

Ribociclib

CDK4/6 inhibitor

Ribociclib (LEE-011, LEE011) is a potent, highly selective, orally bioavailable CDK4/6 inhibitor with IC50 of 10/39 nM, respectively.
PC-20691

NCGC00131308

IQGAP1-Cdc42 inhibitor

NCGC00131308 is a small molecule inhibitor that effectively disrupts IQGAP1-Cdc42 interaction in breast cancer cells, shows EC50 of 4.47 uM in biochemical HTRF assays.
PC-20589

Abemaciclib

CDK4/6 inhibitor

Abemaciclib (LY2835219) is a potent, selective and competitive ATP CDK4/6 inhibitor with Ki values of 0.6 and 2.4 nM for CDK4/cyclin D1 and CDK6/cyclin D1, respectively.
PC-20566

Apcin-A

APC inhibitor

Apcin-A, an Apcin derivative, is an anaphase-promoting complex (APC) inhibitor, interacts strongly with Cdc20, and inhibits the ubiquitination of Cdc20 substrates.
PC-20494

Cdk5i peptide

Cdk5/p25 inhibitor

Cdk5i peptide is a Cdk5-derived 12-amino acid long Cdk5-derived peptide that interferes with the Cdk5/p25 complex with Kd of 0.17 uM, 40-fold more strongly to either Cdk5 or Cdk2 alone.
PC-20345

Cdc25A inhibitor 7h

Cdc25A inhibitor 7h is a specific small molecule Cdc25A inhibitor, inhibits Cdc25A phosphatase activity, blocks loss of mitochondrial activity, and inhibits caspase-3 activation caused by NGF deprivation and 6-OHDA.
PC-20344

Cdc25A inhibitor 7g

Cdc25A inhibitor 7g is a specific small molecule Cdc25A inhibitor, inhibits Cdc25A phosphatase activity, blocks loss of mitochondrial activity, and inhibits caspase-3 activation caused by NGF deprivation and 6-OHDA.
PC-20315

LGR6768

CDK7 inhibitor

LGR6768 is a potent, selective CDK7 inhibitor with IC50 of 20 nM, >12-fold selectivity over other CDKs.
PC-20284

QR-6401

CDK2 inhibitor

QR-6401 (QR6401) is a highly potent, selective, oral macrocyclic CDK2 inhibitor.

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