Cat. No. |
Product Name |
Information |
PC-42578 |
PHA-848125
CDK/TRK inhibitor
|
Milciclib (PHA-848125) is a potent, selective, brain penetrant and orally available dual CDK and TRK inhibitor with IC50 of 45 and 53 nM for CDK2/cyclin A and TrkA, respectively. |
PC-45913 |
AT-7519 hydrochloride
CDK2 inhibitor
|
AT-7519 hydrochloride (AT7519) is a potent, selective CDK2 inhibitor with IC50 of 47 nM, also inhibits CDK1/4/5 with IC50 of 190/67/18 nM and shows selectivity over some kinases (Aurora A, IR kinase, MEK, PDK1, c-Abl, IC50>10 uM). |
PC-45912 |
AT-7519 trifluoroacetate
CDK2 inhibitor
|
AT-7519 trifluoroacetate (AT7519) is a potent, selective CDK2 inhibitor with IC50 of 47 nM, also inhibits CDK1/4/5 with IC50 of 190/67/18 nM and shows selectivity over some kinases (Aurora A, IR kinase, MEK, PDK1, c-Abl, IC50>10 uM). |
PC-45911 |
AT-7519
CDK2 inhibitor
|
AT-7519 (AT7519) is a potent, selective CDK2 inhibitor with IC50 of 47 nM, also inhibits CDK1/4/5 with IC50 of 190/67/18 nM and shows selectivity over some kinases (Aurora A, IR kinase, MEK, PDK1, c-Abl, IC50>10 uM). |
PC-42052 |
SNS-032
CDK2/7/9 inhibitor
|
SNS-032 (BMS-387032) is a potent and selective inhibitor of CDK 2/7/9 with IC50 of 48 nM/62 nM/4 nM, respectively. |
PC-42616 |
Dinaciclib
CDK inhibitor
|
Dinaciclib (SCH 727965) is a potent and selective CDK inhibitor with IC50 of 1, 1, 3 and 4 nM against CDK2, CDK5, CDK1 and CDK9, respectively. |
PC-42425 |
Senexin B
CDK8/CDK19 inhibitor
|
Senexin B (SNX2-1-165) is a highly potent, selective and orally available CDK8/CDK19 inhibitor with IC50 of 24-50 nM. |
PC-42527 |
JNJ-7706621
CDK/Aurora inhibitor
|
JNJ-7706621 is a potent, dual CDK/Aurora kinase inhibitor with IC50 of 9/4/11/15 nM for CDK1/CDK2/Aurora A/Aurora B respectively. |
PC-22032 |
KY-273
CDK8/19 inhibitor
|
KY-273 (KY273) is a potent, specific CDK8/19 inhibitor with IC50 of 29.1 and 44.7 nM respectively, promotes osteoblast differentiation and has cortical-bone-selective osteogenic effects. |
PC-21964 |
dCeMM4
Cyclin K degrader
|
dCeMM4 is a small glue degrader, induces ubiquitination and degradation of cyclin K by prompting an interaction of CDK12-cyclin K with a CRL4B ligase complex. |
PC-21963 |
dCeMM3
Cyclin K degrader
|
dCeMM3 is a small glue degrader, induces ubiquitination and degradation of cyclin K by prompting an interaction of CDK12-cyclin K with a CRL4B ligase complex. |
PC-21962 |
dCeMM2
Cyclin K degrader
|
dCeMM2 is a small glue degrader, induces ubiquitination and degradation of cyclin K by prompting an interaction of CDK12-cyclin K with a CRL4B ligase complex. |