| Cat. No. |
Product Name |
Information |
| PC-42036 |
LY3177833
CDC7 inhibitor
|
LY3177833 is a potent and selective CDC7 inhibitor with IC50 of 3.3 nM. |
| PC-42060 |
AZD-5438
CDK1/2/9 inhibitor
|
AZD-5438 (AZD5438) potent and oral inhibitor of CDK1/2/9 with IC50 of 16/6/20 nM, respectively. |
| PC-42425 |
Senexin B
CDK8/CDK19 inhibitor
|
Senexin B (SNX2-1-165, BCD-115) is a highly potent, selective and orally available CDK8/CDK19 inhibitor with IC50 of 24-50 nM. |
| PC-42527 |
JNJ-7706621
CDK/Aurora inhibitor
|
JNJ-7706621 is a potent, dual CDK/Aurora kinase inhibitor with IC50 of 9/4/11/15 nM for CDK1/CDK2/Aurora A/Aurora B respectively. |
| PC-28041 |
CDK12-IN-3
CDK12 inhibitor
|
CDK12-IN-3 is a potent, selective, noncovalent CDK12 inhibitor with IC50 of 491 nM, inhibits phosphorylation of Ser2 on the C-terminal repeat domain of RNA polymerase II. |
| PC-27675 |
RGB-286638 free base
CDK inhibitor
|
RGB-286638 free base is a small-molecule multi-targeted cyclin-dependent kinase (CDK) inhibitor with IC50 of 1-5 nM for cyclin T1-CDK9, cyclin B1-CDK1, cyclin E-CDK2, cyclin D1-CDK4, cyclin E-CDK3, and p35-CDK5. |
| PC-27637 |
Cucurbitacin E
Cyclin B1 inhibitor
|
Cucurbitacin E (α-elaterin) is a strong antifeedant natural compound with the ability to disrupt cell actin and cell adhesion, induces CRC G2/M phase arrest via cell division cycle gene 2 (CDC2) downregulation and dissociation of the cyclin B1/CDC2 complex. |
| PC-27526 |
CID-078
Cyclin A/B-RxL inhibitor
|
CID-078 is a highly potent, first-in-class, oral macrocycle cyclin A/B-RxL inhibitor with IC50 of <0.02 uM for both cyclin A and cyclin B in FP assays, Kd of 1.1 nM and 0.83 nM for cyclin A and cyclin B respectively. |
| PC-27520 |
TK22
EndMT inhibitor, Multikinases inhibitor
|
TK22 is a small molecule that selectively erases Endothelial-to-mesenchymal transition (EndMT)-competent endothelial state and reverses experimental pulmonary hypertension, inhibits interphase cell-cycle kinases CDK2/3/4/6 node as well as a pro-mesenchymal node of AMPK-related kinases (NUAK1 and SIK1/2/3) together with PDGFRβ and MLK3. |
| PC-27232 |
Cdc7 inhibitor 89S
CDC7 inhibitor
|
Cdc7 inhibitor 89S is a potent, ATP mimetic inhibitor of Cdc7 kinase with Ki of 0.5 nM, inhibits cell proliferation of different tumor cell lines with IC50 in submicromolar range, and exhibits in vivo tumor growth inhibition of 68% in the A2780 xenograft model. |
| PC-27231 |
XL413
CDC7 inhibitor
|
XL413 (BMS-863233) is a potent, selective, ATP competitive serine/threonine kinase CDC7 inhibitor with IC50 of 3.4 nM. |
| PC-26497 |
RO8323
CDK8/19 inhibitor
|
RO8323 is a potent and selective dual CDK8/19 inhibitor with IC50 of 2/3 nM respectively, has 100-fold kinome selectivity. |
