| Cat. No. |
Product Name |
Information |
| PC-27637 |
Cucurbitacin E
Cyclin B1 inhibitor
|
Cucurbitacin E (α-elaterin) is a strong antifeedant natural compound with the ability to disrupt cell actin and cell adhesion, induces CRC G2/M phase arrest via cell division cycle gene 2 (CDC2) downregulation and dissociation of the cyclin B1/CDC2 complex. |
| PC-27526 |
CID-078
Cyclin A/B-RxL inhibitor
|
CID-078 is a highly potent, first-in-class, oral macrocycle cyclin A/B-RxL inhibitor with IC50 of <0.02 uM for both cyclin A and cyclin B in FP assays, Kd of 1.1 nM and 0.83 nM for cyclin A and cyclin B respectively. |
| PC-27520 |
TK22
EndMT inhibitor, Multikinases inhibitor
|
TK22 is a small molecule that selectively erases Endothelial-to-mesenchymal transition (EndMT)-competent endothelial state and reverses experimental pulmonary hypertension, inhibits interphase cell-cycle kinases CDK2/3/4/6 node as well as a pro-mesenchymal node of AMPK-related kinases (NUAK1 and SIK1/2/3) together with PDGFRβ and MLK3. |
| PC-27232 |
Cdc7 inhibitor 89S
CDC7 inhibitor
|
Cdc7 inhibitor 89S is a potent, ATP mimetic inhibitor of Cdc7 kinase with Ki of 0.5 nM, inhibits cell proliferation of different tumor cell lines with IC50 in submicromolar range, and exhibits in vivo tumor growth inhibition of 68% in the A2780 xenograft model. |
| PC-27231 |
XL413
CDC7 inhibitor
|
XL413 (BMS-863233) is a potent, selective, ATP competitive serine/threonine kinase CDC7 inhibitor with IC50 of 3.4 nM. |
| PC-26497 |
RO8323
CDK8/19 inhibitor
|
RO8323 is a potent and selective dual CDK8/19 inhibitor with IC50 of 2/3 nM respectively, has 100-fold kinome selectivity. |
| PC-26429 |
CDK11 inhibitor 37
CDK11 inhibitor
|
CDK11 inhibitor 37 is a potent, selective CDK11 inhibitor with IC50 of 4 nM, exhibits clean kinome selectively. |
| PC-26368 |
CDK9 inhibitor C35
CDK9 inhibitor
|
CDK9 inhibitor C35 is a potent, selective and orally bioavailable CDK9 inhibitor with IC50 of 17.44 nM, shows 18-fold selectivity over CDK2. |
| PC-26367 |
CDK9 inhibitor HS34
CDK9 inhibitor
|
CDK9 inhibitor HS34 is a potent, selective CDK9 inhibitor with IC50 of 1.4 nM (CDK9/CycT1), shows 250-fold selectivity over CDK2/CycA2. |
| PC-26363 |
Vustanaciclib
CDK2/4/6 inhibitor
|
Vustanaciclib (GDC-4198, RGT-419B) is a potent CDK2/4/6 inhibitor. |
| PC-26145 |
HQY1428
cyclin K degrader
|
HQY1428 is an oral availabile cyclin K molecular glue degrader, promotes CDK12 condensation in nuclear speckles and accelerates proteasomal degradation of CDK12-cyclin K, shows potent single-agent antitumor activity and synergistic efficacy with HER2 inhibitors. |
| PC-25879 |
ZLY025
cyclin K degrader
|
ZLY025 is a highly potent, selective Cyclin K (CCNK) degrader with DC50 of 42.7 nM and Dmax>93%, exhibits broad-spectrum antitumor activity. |
