| Cat. No. |
Product Name |
Information |
| PC-20431 |
HBK001
DPP4 inhibitor and GPR119 agonist
|
HBK001 (HBK-001) is a dual-target DPP4 inhibitor and GPR119 agonist with IC50 of 66 nM for DPP4 and EC50 of 30 nM for GPR119 transactivation activity. |
| PC-20430 |
YH18968
GPR119 agonist
|
YH18968 is a novel potent, selective GPR119 receptor agonist, potently induces intracellular cAMP accumulation with EC50 of 2.8 nM. |
| PC-20429 |
APD597
GPR119 agonist
|
APD597 (JNJ-38431055) is a potent, selective GPR119 agonist with EC50 of 46 nM and 421 nM for human and rat GPR119, respectively. |
| PC-20428 |
ZB-16
GPR119 agonist
|
ZB-16 (ZB40-0016) is a potent, selective GPR119 agonist, increase intracellular cAMP with EC50 of 7.25 nM, stimulates incretin secretion. |
| PC-20426 |
AR231453
GPR119 agonist
|
AR231453 (AR 231453) is the first potent, selective and orally efficacious GPR119 agonist with EC50 of 0.68 nM. |
| PC-63460 |
MK-8282
|
MK-8282 is a potent, selective, oral GPR119 agonist with EC50 of 10 and 58 nM for hGPR119 and mGPR119, respectively. |
| PC-42879 |
GSK1292263
|
GSK1292263 is a novel potent, selective GPR119 agonist, elevates circulating glucose-dependent insulinotropic peptide, GLP-1 and peptide tyrosine-tyrosine in nonclinical models of diabetes, with no effect on plasma glucose.. |
| PC-60821 |
GSK 2041706
|
A potent, selective and orally bioavailable GPR119 agonist with EC50 of 4 nM, with good selectivity versus a battery of receptors, ion channels and enzymes. |
