| Cat. No. |
Product Name |
Information |
| PC-42249 |
CXD101
class I HDAC inhibitor
|
Zabadinostat (CXD101) is a potent, selective and orally active class I HDAC inhibitor with IC50s of 63 nM, 570 nM and 550 nM for HDAC1, HDAC2 and HDAC3, respectively, has no activity against class II HDACs. |
| PC-42671 |
Valproic acid sodium salt
HDAC inhibitor
|
Valproic acid sodium salt is a HDAC inhibitor that selectively inhibits the catalytic activity of class I HDACs, and induces proteasomal degradation of HDAC2. |
| PC-42670 |
Valproic acid
HDAC inhibitor
|
Valproic acid is a HDAC inhibitor that selectively inhibits the catalytic activity of class I HDACs, and induces proteasomal degradation of HDAC2. |
| PC-42421 |
EDO-S101
HDAC inhibitor, DNA alkylator
|
EDO-S101 (Tinostamustine) is a fusion molecule comprising of the alkylator bendamustine and the HDAC-inhibitor vorinostat. |
| PC-42767 |
Abexinostat
HDAC inhibitor
|
PCI-24781 (Abexinostat, CRA 024781) is a broad spectrum HDAC inhibitor, inhibits pure recombinant HDAC1 with Ki of 7 nM. |
| PC-42126 |
HDACi-4b
HDAC inhibitor
|
A benzamide-type HDAC inhibitor with IC50 of 78 uM for changes of FXN mRNA in affected GM15850 cells. |
| PC-25614 |
ITF-6475
HDAC6 inhibitor
|
ITF-6475 is a potent, selective histone deacetylase 6 (HDAC6) inhibitor with IC50 of 7.7 nM (human full-length HDAC6), ITF-6475 is highly selective for the CD2 domain (zHDAC6-CD2), shows <10,000-fold selectivity for HDAC6 over all other HDAC subtypes. |
| PC-25412 |
SYSUP007
HDAC inhibitor
|
SYSUP007 is a derivative of the FTO inhibitor rhein, and HDAC and SGK1 inhibitor, inhibits the proliferation of human GBM cells. |
| PC-25411 |
Parthenolide
HDAC1 inhibitor, USP10 inhibitor
|
Parthenolide is a sesquiterpene lactone found in the medicinal herb Feverfew, exhibits anti-inflammatory activity by inhibiting NF-κB activation, impairs breast cancer cell proliferation via inhibitiong USP10, also inhibits HDAC1 protein without affecting other class I/II HDACs. |
| PC-25393 |
OCP-001
HDAC1 inhibitor
|
OCP-001 is a potent, highly selective HDAC1 inhibitor, dose-dependently inhibits osteoclast differentiation. |
| PC-25178 |
J22352
HDAC6 inhibitor
|
J22352 is a potent, highly selective HDAC6 inhibitor with IC50 of 4.7 nM, >2000-fold selective for HDAC6 than for class I HDACs (HDAC1, HDAC2 and HDAC3), and with little activity against HDAC8. |
| PC-25167 |
class I HDACs inhibitor JT86
HDAC1 inhibitor
|
class I HDACs inhibitor JT86 is a potent class I HDACs inhibitor with IC50 of 0.72/8.0/2.0 nM for HDAC1/2/3 respectively, 61-fold selectivity over HDAC8 (IC50 44 nM) and 11-fold over HDAC2. |
