| Cat. No. |
Product Name |
Information |
| PC-25846 |
GCJ-490A
HDAC inhibitor
|
GCJ-490A is a pan-histone deacetylase (HDAC) inhibitor that exerts potent inhibitory activity against HDAC1, HDAC3, and HDAC6 with IC50 of 3.64, 3.02 and 4.96 nM respectively. |
| PC-25614 |
ITF5924
HDAC6 inhibitor
|
ITF5924 is a potent, selective histone deacetylase 6 (HDAC6) inhibitor with IC50 of 7.7 nM (human full-length HDAC6), shows >100-fold selectivity for HDAC6 over all other HDAC subtypes. |
| PC-25411 |
Parthenolide
HDAC1 inhibitor, USP10 inhibitor
|
Parthenolide is a sesquiterpene lactone found in the medicinal herb Feverfew, exhibits anti-inflammatory activity by inhibiting NF-κB activation, impairs breast cancer cell proliferation via inhibitiong USP10, also inhibits HDAC1 protein without affecting other class I/II HDACs. |
| PC-25393 |
OCP-001
HDAC1 inhibitor
|
OCP-001 is a potent, highly selective HDAC1 inhibitor, dose-dependently inhibits osteoclast differentiation. |
| PC-25178 |
J22352
HDAC6 inhibitor
|
J22352 is a potent, highly selective HDAC6 inhibitor with IC50 of 4.7 nM, >2000-fold selective for HDAC6 than for class I HDACs (HDAC1, HDAC2 and HDAC3), and with little activity against HDAC8. |
| PC-25167 |
class I HDACs inhibitor JT86
HDAC1 inhibitor
|
class I HDACs inhibitor JT86 is a potent class I HDACs inhibitor with IC50 of 0.72/8.0/2.0 nM for HDAC1/2/3 respectively, 61-fold selectivity over HDAC8 (IC50 44 nM) and 11-fold over HDAC2. |
| PC-25164 |
Compound 5104434
HDAC1 activator
|
Compound 5104434 is a potent, selective activator of HDAC1, selectively activates HDAC1 without significant effects on HDAC2, HDAC3, or HDAC8. |
| PC-25163 |
Exifone
HDAC1 activator
|
Exifone (Adlone) is a potent activator of the deacetylase activity of HDAC1, increases the rate of deacetylation by the enzyme with EC50 of 0.241 uM and EC1.5 value of 0.031 uM. |
| PC-25110 |
Martinostat
HDAC inhibitor
|
Martinostat is a potent, selective inhibitor for class I and class-IIb HDACs with IC50 of 0.3/2.0/0.6 nM for HDAC1/2/3 and 4.1 nM for HDAC6 respectively, >100-fold selectivity over other HDAC isoforms. |
| PC-24921 |
RM-3-22
HDAC inhibitor
|
RM-3-22 is a TAZQ-based hydroxamic acid derivative and potent HDAC inhibitor with IC50 of 49.9 nM, 68.5 nM, and 12.9 nM for HDAC1, HDAC3, and HDAC6 isoforms respectively. |
| PC-24777 |
MI-192
HDAC2/HDAC3 inhibitor
|
MI-192 is a potent, selective HDAC2 and HDAC3 inhibitor with IC50 of 30 nM and 16 nM, respectively. |
| PC-24773 |
ITF3756
HDAC6 inhibitor
|
ITF3756 (ITF-3756) is a potent, selective HDAC6 inhibitor with IC50 of 17 nM, >80-fold selective versus HDAC8 and HDAC Class IIa isoforms (HDAC4, 5, 7, and 9). |
