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Cat. No. Product Name Information
PC-49614

AM-5308

Kif18A inhibitor

AM-5308 is a potent, selective mitotic kinesin KIF18A inhibitor with IC50 of 47 nM in kinesin-8 microtubule (MT)-ATPase motor assays.
PC-49285

BTB-1

Kif18A inhibitor

BTB-1 (KIF18A inhibitor BTB-1) is a selective and ATP-competitive mitotic kinesin KIF18A inhibitor, BTB-1 potently inhibits the ATPase activity of Kif18A with IC50 of 1.69 uM, does not inhibit other mitotic kinesins.
PC-73363

UMK57

MACK (KIF2C) agonist

UMK57 (UMK 57) is a small-molecule MACK (alias KIF2C) agonist that specifically potentiates the activity of the kinesin‐13 protein MCAK, suppresses chromosome mis-segregation in chromosomal instability (CIN) cancer cells.
PC-72904

AMG650

KIF18A inhibitor

AMG650 (Sovilnesib) is an oral, first in class, selective small molecule inhibitor of KIF18A for treatment of advanced solid tumors.
PC-72726

Azo-EMD

Photoswitchable Eg5 inhibitor

Azo-EMD is a cell permeable, photoswitchable compound that inhibits mitotic kinesin Eg5 more potently in its light-induced cis form, used for optical control mitosis.
PC-63578

Kif15-IN-1

Kif15-IN-1 is a potent, selective inhibitor of KIF15 motility, can act synergistically with Eg5 inhibitors to impair cancer cell proliferation..
PC-62405

MAC1

Eg5 rescuer

MAC1 (Monastrol Antagonizing Compound 1) is a small molecule that can rescue spindle bipolarity in cells lacking Eg5 activity.
PC-70047

HR22C16

Eg5 inhibitor

HR22C16 (Monastroline) is a potent, selective and cell permeable inhibitor of mitotic kinesin Eg5 with IC50 of 0.8 uM, does not interact with other microtubule motor proteins.
PC-42308

Monastrol

Eg5 inhibitor

Monastrol is a potent, specific, allosteric and reversible mitotic kinesin Eg5 inhibitor with IC50 of 14 uM (microtubule motility inhibition).
PC-45861

Ispinesib

Ispinesib (SB-715992) is a potent, selective, cell-permeable, allosteric inhibitor of Eg5 (mitotic kinesin KSP) with Ki of 2.3 nM.
PC-21659

AM-1882

Kif18A inhibitor

AM-1882 (AM1882) is a potent, selective mitotic kinesin KIF18A inhibitor with IC50 of 230 nM in kinesin-8 microtubule (MT)-ATPase motor assays.
PC-21658

AM-9022

Kif18A inhibitor

AM-9022 (AM9022) is a potent, selective and orally active mitotic kinesin KIF18A inhibitor with IC50 of 47 nM in kinesin-8 microtubule (MT)-ATPase motor assays.

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