| Cat. No. |
Product Name |
Information |
| PC-62668 |
ONO-3080573
LPA1 antagonist
|
ONO-3080573 is a potent LPA1 receptor inhibitor with IC50 of 11 nM. |
| PC-61604 |
GSK-1842799
S1P1 agonist
|
GSK-1842799 is a potent, selective, oral bioavailable S1P1 agonist with bind affinity of 0.52 nM. |
| PC-70243 |
Ceralifimod
S1P1/S1P5 agonist
|
Ceralifimod (ONO-4641, MSC-2430913A) is a next-generation S1P receptor agonist selective for S1P1 and S1P5 with EC50 of 0.0273 nM and 0.334 nM. |
| PC-61179 |
NIBR-0213
|
NIBR-0213 is a potent, selective, orally active S1P1 antagonist with IC50 of 2.5 nM Ca2+ mobilization assays, without activity on S1P2, S1P3 and S1P4 (IC50>10 uM). |
| PC-61014 |
CS-0777
S1P1 agonist
|
CS-0777 is a potent, selective, orally active S1P receptor-1 (S1P1) agonist with EC50 of 1.1 nM, 320-fold selectivity over S1P3. |
| PC-60890 |
GRI 977143
LPA2 agonist
|
A potent, specific and nonlipid agonist of LPA2 receptor with EC50 of 3.3 uM, does not activate any of the other LPA GPCRs (>10 uM). |
| PC-60889 |
DBIBB
LPA2 agonist
|
DBIBB is a potent and specific, nonlipid agonist of LPA2 receptor with EC50 of 100 nM, without activating or inhibiting LPA1/3/4/5 receptors. |
| PC-60766 |
SEW2871
S1P1 agonist
|
SEW2871 is a potent, selective S1P1 receptor full agonist with EC50 of 13.8 nM, with no activites at the S1P2-5 receptors. |
| PC-60746 |
AB1
S1P2 inhibitor
|
AB1 is a potent, specific S1P2 receptor (Edg-5) antagonist with IC50 of 3 nM, with no agonistic or antagonistic activities on other S1PRs. |
| PC-60745 |
JTE 013
S1P2 inhibitor
|
JTE-013 (JTE013) is a potent, specific S1P2 receptor (Edg-5) antagonist with IC50 of 17 nM and 22 nM for human and rat S1P2, respectively. |
| PC-60340 |
AD 2900
S1P inhibitor
|
AD 2900 (AD2900, AD-2900) is a novel potent, broad S1P receptor antagonist with IC50 of 3.8, 3.2, 6.2, 5.9 and 0.405 uM for S1P1, 2, 3, 4 and 5 respectively. |
| PC-60145 |
ONO-0300302
LPA1 antagonist
|
ONO-0300302 (ONO0300302) is a novel potent, slow tight binding LPA1 receptor antagonist with IC50 of 86 nM, Kd of 0.34 nM. |
