| Cat. No. |
Product Name |
Information |
| PC-72349 |
BMS-986278
LPA1 antagonist
|
BMS-986278 (BMS986278) is a potent, selective lysophosphatidic acid receptor 1 (LPA1) antagonist with human LPA1 Kb of 6.9 nM. |
| PC-35275 |
SAR-100842
LPA1 antagonist
|
Fipaxalparant (SAR100842) is a potent, selective, orally available antagonist of the Lysophosphatidic Acid 1 Receptor (LPA1 receptor) with IC50 of 31 nM in β-arrestin assays. |
| PC-35273 |
TAK-615
LPA1 antagonist
|
TAK-615 (TAK615) is a potent, selective, negative allosteric modulator (NAM) of the LPA1 receptor, partially inhibits the LPA response with IC50 of 91 nM (60% at 10 uM) in calcium mobilisation assays.. |
| PC-35245 |
BMS-986166
S1P modulator
|
BMS-986166 (Udifitimod) is a potent, selective S1P receptor modulator for the treatment of ulcerative colitis. |
| PC-35197 |
ASP6432
LPA1 antagonist
|
ASP6432 (ASP-6432) is a potent and selective antagonist of LPA1 receptor, does-dependently inhibits LPA-stimulated increase in intracellular calcium ion with IC50 of 11 nM. |
| PC-43463 |
Ki16425
LPA/LPA3 antagonist
|
Ki16425 is a potent, subtype-selective, competitive antagonist of lysophosphatidic acid receptor LPA1, LPA2 and LPA3 with Ki of 0.34 μM, 6.5 μM and 0.93 μM, shows no activity at LPA4, LPA5, LPA6. |
| PC-43209 |
Etrasimod
S1P1 antagonist
|
Etrasimod (APD334) is a potent, selective, centrally available S1P1 receptor antagonist with β-arrestin EC50 of 6.1 nM, internalizes human S1P1 in CHO cells expressing HA tagged S1P1 with IC50 of 1.88 nM. |
| PC-43000 |
Siponimod
S1P1/S1P5 modulator
|
Siponimod (BAF312) is a potent, selective S1P1/S1P5 receptor modulator with EC50 of 0.39/0.0.98 nM, >1,000-fold selectivity over S1P2/3/4. |
| PC-63010 |
W146
S1P1 antagonist
|
W146 is a potent, selective S1P1 antagonist with Ki of 18 nM, displays no effect at S1P2, S1P3 or S1P5, enhances capillary leakage and restores lymphocyte egress in vivo. . |
| PC-63009 |
CYM5442
S1P1 agonist
|
CYM 5442 is a potent and selective S1P1 agonist with EC50 of 1.35 nM. |
| PC-62670 |
ONO-9780307
LPA1 inhibitor
|
ONO-9780307 is a potent, specific lysophosphatidic acid receptor 1 (LPA1) inhibitor with IC50 of 27 nM. |
| PC-62669 |
ONO-9910539
LPA1 antagonist
|
ONO-9910539 is a potent LPA1 receptor inhibitor with IC50 of 22 nM. |
