| Cat. No. |
Product Name |
Information |
| PC-22065 |
ESB1609
S1P5 agonist
|
ESB1609 is a potent, selective, next-generation S1P5 receptor agonist with EC50 of 70 nM at the human S1P5 receptor, has >700-fold selectivity over human S1P1, S1P2, S1P3, and S1P4 receptors (EC50>5 uM). |
| PC-21751 |
ACT-1016-0707
LPA1 inhibitor
|
ACT-1016-0707 is a potent, selective, and orally active lysophosphatidic acid receptor subtype 1 receptor (LPA1 receptor, LPAR1) antagonist with IC50 of 3.1 nM, highly selective over LPAR2 or LPAR3. |
| PC-21569 |
HL001
LPA1 antagonist
|
HL001 is a novel lysophosphatidic acid 1 (LPA1) receptor antagonist, suppresses fibrosis-associated subpopulations of fibroblasts, exhibits significant anti-fibrotic effects both in murine models and human organoid models. |
| PC-21441 |
NXC736 hydrochloride
S1PR4 inhibitor
|
NXC736 hydrochloride (SLB736) is a selective functional antagonist for type 4 sphingosine-1-phosphate receptor (S1PR4), has immunomodulatory and anti-fibrotic effects. |
| PC-21122 |
TP0541640
LPA1 antagonist
|
TP0541640 (TP 0541640) is a novel potent LPA1 antagonist with IC50 of 1.6 nM, shows potential for the treatment of lung and skin fibrosis. |
| PC-20833 |
A-971432
S1P5 agonist
|
A-971432 is a potent, highly selective, CNS-penetrant and orally bioavailable agonist of S1P5 receptor with EC50 values of 4.1 and 5.7 nM in cAMP and GTPγS assays, respectively. |
| PC-20759 |
ONO-0740556
LPA1 agonist
|
ONO-0740556 is a small molecule agonist of lysophosphatidic acid receptor 1 (LPA1) with EC50 of 0.26 nM (human LPA1), ONO-0740556 is an LPA analog with more potent activity against LPA1. |
| PC-20351 |
IMMH002
S1P1 agonist
|
IMMH002 is a potent, selective and orally active S1P1 agonist, IMMH002 can be transformed to IMMH002-P in vivo, IMMH002-P activates S1P1, S1P4, and S1P5 with 12.4, 19.8 and 29.4 nM respectively. |
| PC-38575 |
CS-2100
S1P1 agonist
|
CS-2100 is a potent, selective, orally active S1P1 agonist with EC50 of 4.0 nM, over 5000-fold selectivity against S1P3. |
| PC-38465 |
CYM 5520
S1PR2 agonist
|
CYM 5520 is a potent, selective sphingosine 1-phosphate receptor 2 (S1PR2) allosteric agonist with EC50 of 480 nM, does not activate other S1P receptors. |
| PC-38431 |
Zectivimod
S1P receptor agonist
|
Zectivimod is a sphingosine-1-phosphate (S1P) receptor agonist. |
| PC-38427 |
Vibozilimod
S1PR1 agonist
|
Vibozilimod (SCD 044) is an orally-available, potent, selective sphingosine-1-phosphate receptor-1 (S1PR1) agonist with EC50 of 0.2 nM. |
