| Cat. No. |
Product Name |
Information |
| PC-42800 |
Fingolimod
S1P receptor agonist
|
Fingolimod (FTY720) is an immunomodulatory agent can be phosphorylated by SphK, then functions as a potent agonist of S1P receptors (S1P1/3/4/5) with EC50 of 0.3-5 nM. |
| PC-42213 |
BMS-986020
LPA1 antagonist
|
BMS-986020 (BMS986020, AM152) is a potent, selective, orally available LPA1 receptor antagonist with Kb value of 6.7 nM. |
| PC-42656 |
Ponesimod
S1P1 agonist
|
Ponesimod (ACT-128800) is a potent, selective, orally active S1P1 receptor agonist with EC50 of 9.1 nM. |
| PC-45411 |
LPA2 antagonist 1
LPA2 antagonist
|
LPA2 antagonist 1 is a potent, selective LPA2 (EDG4) antagonist with IC50 of 17 nM. |
| PC-42950 |
Ozanimod
S1P1/S1P5 agonist
|
Ozanimod (RPC-1063) is a potent, selective agonist of S1P1 and S1P5 receptor with EC50 of 0.41 nM and 11 nM respectively. |
| PC-42341 |
Icanbelimod
S1PR agonist
|
Icanbelimod (CBP-307) is a highly potent, next-generation highly potent sphingosine-1-phosphate receptor (S1PR) agonist with EC50 of 3.55 nM (S1PR1), specifically targets S1PR1/4/5. |
| PC-45386 |
Cenerimod
S1P1 agonist
|
Cenerimod (ACT-334441) is a potent and orally available S1P1 receptor agonist with EC50 of 2.7 nM. |
| PC-45066 |
Amiselimod hydrochloride
S1P1 modulator
|
Amiselimod (MT-1303) hydrochloride is a prodrug S1P1 receptor modulator lacking S1P3 receptor agonism to avoid bradycardia associated with fingolimod and other S1P receptor modulators. |
| PC-42284 |
ONO-7300243
LPA1 inhibitor
|
ONO7300243 is a novel potent, selective, orally available lysophosphatidic acid receptor 1 (LPA1) antagonist with IC50 of 0.16 uM. |
| PC-42379 |
CYM-5541
S1P3 agonist
|
CYM-5541 (ML249) is a potent, selective, allosteric and full agonist of S1P3 receptor with EC50 of 72-132 nM. |
| PC-27269 |
ASP4058 hydrochloride
S1P1/S1P5 agonist
|
ASP4058 hydrochloride is a potent, next-generation S1P receptor agonist selective for S1P1 and S1P5 with EC50 of 7.4 nM and 7.5 nM respectively. |
| PC-27268 |
ASP4058
S1P1/S1P5 agonist
|
ASP4058 is a potent, next-generation S1P receptor agonist selective for S1P1 and S1P5 with EC50 of 7.4 nM and 7.5 nM respectively. |
