| Cat. No. |
Product Name |
Information |
| PC-70075 |
VPC-23019
|
VPC-23019 is a competitive S1P receptor antagonist with pKi of 7.86 and 5.93 for S1P1 and S1P3, respectively, in radioligand binding assays. |
| PC-60095 |
SPM-242 racemate
|
A potent, selective S1P3 antagonist with Ki of 0.25 nM. |
| PC-60094 |
SPM-242
|
A potent, selective S1P3 antagonist with Ki of 0.25 nM. |
| PC-60049 |
Mocravimod
S1P1 agonist
|
Mocravimod (KRP203) is a synthetic immunosuppressant that functions as a S1P1 receptor agonist. |
| PC-42800 |
Fingolimod
S1P receptor agonist
|
Fingolimod (FTY720) is an immunomodulatory agent can be phosphorylated by SphK, then functions as a potent agonist of S1P receptors (S1P1/3/4/5) with EC50 of 0.3-5 nM. |
| PC-42213 |
BMS-986020
LPA1 inhibitor
|
BMS-986020 (BMS986020, AM-152) is a potent, selective, orally available LPA1 receptor antagonist for treating idiopathic pulmonary fibrosis. |
| PC-42656 |
Ponesimod
S1P1 agonist
|
Ponesimod (ACT-128800) is a potent, selective, orally active S1P1 receptor agonist with EC50 of 9.1 nM. |
| PC-42950 |
Ozanimod
S1P1/S1P5 agonist
|
Ozanimod (RPC-1063) is a potent, selective agonist of S1P1 and S1P5 receptor with EC50 of 0.41 nM and 11 nM respectively. |
| PC-45386 |
Cenerimod
|
Cenerimod (ACT-334441) is a potent and orally available S1P1 receptor agonist with EC50 of 2.7 nM. |
| PC-45066 |
Amiselimod hydrochloride
S1P1 modulator
|
Amiselimod (MT-1303) hydrochloride is a prodrug S1P1 receptor modulator lacking S1P3 receptor agonism to avoid bradycardia associated with fingolimod and other S1P receptor modulators. |
| PC-42284 |
ONO-7300243
LPA1 inhibitor
|
ONO7300243 is a novel potent, selective, orally available lysophosphatidic acid receptor 1 (LPA1) antagonist with IC50 of 0.16 uM. |
| PC-42379 |
CYM-5541
S1P3 agonist
|
CYM-5541 (ML249) is a potent, selective, allosteric and full agonist of S1P3 receptor with EC50 of 72-132 nM. |
