| Cat. No. |
Product Name |
Information |
| PC-45630 |
Didox
Ribonucleotide reductase inhibitor
|
Didox is a ribonucleotide reductase (RNR) inhibitor; overcomes Bcl-2 mediated radiation resistance in PC-3 cells, inhibits LPS-induced mRNA levels of iNOS, IL-6, IL-1, TNF-α, NF-κβ (p65), and p38-α. |
| PC-42711 |
Raltitrexed
Antifolate
|
Raltitrexed (ZD1694, D1694, ICI-D1694) is a quinazoline antifolate thymidylate synthase (TS) inhibitor with Ki of 62 nM. |
| PC-42266 |
Triapine
RRM2 inhibitor
|
Triapine (3-AP, PAN-811, OCX191, NSC 663249) is a potent inhibitor of ribonucleotide reductase subunit M2 (RRM2) with broad spectrum antitumor activity. |
| PC-42285 |
Acelarin
|
Acelarin (NUC-1031, CPF-31) is a gemcitabine phosphoramidate prodrug that can overcome the key cancer resistance |
| PC-45223 |
Tegafur
CAS 17902-23-7
|
Tegafur is a chemotherapeutic prodrug of 5-flourouracil (5-FU) used in the treatment of cancers, a thymidylate synthase inhibitor. |
| PC-42672 |
5-Azacytidine
|
5-Azacytidine (5-AzaC, Azacitidine) is a chemical analog of Cytidine that inhibits DNA methyltransferase, induces mitochondrial apoptosis and autophagy. |
| PC-27576 |
TAS-102
Nucleoside Antimetabolite
|
TAS-102 (Trifluridine/tipiracil hydrochloride mixture) is a 1:0.5 mixture of alpha,alpha,alpha-trifluorothymidine (FTD) and 5-chloro-6-[1-(2-iminopyrrolidinyl)methyl]-2,4(1H,3H)-pyrimidinedione hydrochloride thymidine phosphorylase inhibitor (TPI), inhibits thymidilate synthase (TS) and incorporation into DNA. |
| PC-27515 |
MB07133
Nucleoside analog
|
Zefoscytarabine (MB-7133, MB07133) is a liver-targeted prodrug of cytarabine mononucleotide (araCMP) and a DNA polymerase inhibitor inhibits DNA synthesis, selectively releases the monophosphate of a nucleoside (NMP) into CYP3A4-expressing cells, such as hepatocytes. |
| PC-27240 |
dCTPP1-IN-1
dCTPP1 inhibitor
|
dCTPP1-IN-1 is a potent, selective dCTP pyrophosphatase 1 (dCTPase, dCTPP1) inhibitor with IC50 of 36 nM, increases dCTPase thermal and protease stability, displays outstanding selectivity over related enzymes and synergizes with cytidine analogue against leukemic cells. |
| PC-26914 |
Piritrexim
DHFR inhibitor, Antifolate
|
Piritrexim (BW301U) is a lipophilic antifolate and potent dihydrofolate reductase (DHFR) inhibitor against Pneumocystis carinii and Toxoplasma gondii, with IC50 of 0.038 and 0.011 uM, respectively, shows antiparasitic, antipsoriatic and antitumor properties. |
| PC-26912 |
Leucovorin
Antifolate
|
Leucovorin (folinic acid, calcium folinate) is a prescription form of reduced folic acid that does not require enzymatic activation by dihydrofolate reductase (DHFR), prevents side effects from certain medications, such as methotrexate. |
| PC-26703 |
PSB-24379
CD39 inhibitor
|
PSB-24379 is a potent, selective inhibitor of ATP-hydrolyzing ectoenzyme nucleoside triphosphate diphosphohydrolase-1 (NTPDase1, CD39) with Ki of 77.4 nM, shows ancillary CD73 inhibition with Ki of 240 nM. |
