| Cat. No. |
Product Name |
Information |
| PC-26164 |
NF023
P2X1 antagonist
|
NF023 hexasodium is a potent, selective and competitive P2X1 receptor (P2X1R) antagonist with IC50 of 0.21 uM (human P2X1), >100-fold selective over P2X3, P2X2, and P2X4 receptors. |
| PC-26163 |
BzATP triethylammonium salt
P2X receptors agonist
|
BzATP triethylammonium salt is a broad P2X receptors agonist with pEC50 values of 8.74, 5.26, 7.10, 7.50, 6.19, 6.31, 5.33 for P2X1, P2X2, P2X3, P2X2/3, P2X4 and P2X7, respectively. |
| PC-26162 |
PSB-15417
P2X4 antagonist
|
PSB-15417 is a potent, specific P2X4 receptor (P2X4R) antagonist with IC50 of 21.9 nM and 37 nM for human and rat P2X4 receptor, shows limited activity against P2X1, P2X2, P2X3 and P2X7 receptors (All IC50>2 uM). |
| PC-26161 |
PSB-12062
P2X4 antagonist
|
PSB-12062 is a potent, specific P2X4 receptor antagonist with IC50 of 1.38 uM, >35-fold selective over P2X1, P2X2, P2X3 and P2X7 receptors. |
| PC-26160 |
MRS4719
P2X4 antagonist
|
MRS4719 is a potent, selective P2X4 receptor antagonist with IC50 of 0.5 uM (human P2X4R), selective versus hP2X1R, hP2X2/3R, hP2X3R. |
| PC-26159 |
PSB-0704
P2X4 antagonist
|
PSB-0704 is a potent, allosteric P2X4 receptor inhibitor with IC50 of 12.5 and 0.07 uM for human wt P2X4 and P2X4-E307T receptor mutant. |
| PC-26158 |
Cibacron Blue
P2X receptor modulator
|
Cibacron Blue is a non-selective allosteric modulator of P2X2, P2X3, and P2X4 receptors, shows anti-inflammatory and antiarthritic, anti-cancer activites, also inhibits R46 β-lactamase with Ki of 1.2 uM. |
| PC-25895 |
PSFL1191
hP2X7 antagonist
|
PSFL1191 is a potent, species-specific inhibitor for human and panda P2X7 receptors with IC50 of 248 nM (hP2X7) and 754 nM (pdP2X7), but inactive against rodents P2X7 (mP2X7/rP2X7, IC50>30 uM). |
| PC-25894 |
GW791343
P2X7 antagonist
|
GW791343 dihydrochloride is a selective, allosteric antagonist with negative allosteric effects at the human P2X7 receptor with pIC50 of 6.9-7.2, but is a positive allosteric modulator of the rat P2X(7) receptor. |
| PC-25643 |
Gefapixant citrate
P2X3 antagonist
|
Gefapixant citrate (AF-219, MK-7264) is an orally active, small molecule antagonist of P2X3-containing receptor with IC50 of 30 nM (hP2X3 homotrimer) and 100-250 nM (hP2X2/3 heterotrimer). |
| PC-25573 |
HW091077
P2X3 antagonist
|
HW091077 is a potent, selective P2X3 receptor (P2X3R) antagonist with IC50 of 17 nM, shows balanced selectivity versus P2X2/3 (IC50=190 nM). |
| PC-25572 |
UB-MBX-46
P2X7 antagonist
|
UB-MBX-46 is a potent, selective and allosteric antagonist of human P2X7 receptor (hP2X7R) antagonist with IC50 of 0.514 nM, 40.6 nM and 4.52 nM for human, rat and mouse P2X7R respectively. |
