| Cat. No. |
Product Name |
Information |
| PC-43304 |
AZ6102
TNKS1/2 inhibitor
|
AZ6102 is a potent, selective inhibitor of tankyrase TNKS1/2 with IC50 of 3/1 nM, displays >100-fold selectivity against other PARP family enzymes (PARP1/2/6). |
| PC-43035 |
G007-LK
TNKS1/2 inhibitor
|
G007-LK is a potent, specific, metabolically stable TNKS1/2 inhibitor with IC50 of 46 nM and 25 nM, respectively. |
| PC-43025 |
E7449
PARP/TNKS inhibitor
|
E7449 (2X-121) is a potent, orally bioavailable, brain penetrable dual inhibitor of PARP1/2 and TNKS1/2 with IC50 of 2.0/1.0 nM (PARP1/2), 50-100 nM (TNKS1/2). |
| PC-42349 |
Veliparib
PARP inhibitor
|
Veliparib (ABT-888) is a potent, BBB penetrant, and orally active PARP inhibitor with IC50 of 5.2 and 2.9 nM for PARP-1 and PARP-2, respectively. |
| PC-42846 |
AG14361
PARP-1 inhibitor
|
AG14361 is a potent, specific and competitive inhibitor of PARP-1 with Ki of 5.8 nM. |
| PC-42837 |
INO-1001
PARP inhibitor
|
INO-1001 is a potent, selective poly(ADP-ribose) polymerase (PARP). |
| PC-42830 |
BSI-201
PARP1 inhibitor
|
BSI-201 (Iniparib, NSC 746045, IND-71677, SAR240550) is a potent, small molecule PARP1 inhibitor with strong anti-neoplastic effect, demonstrates the potential treatment of breast cancer. |
| PC-62699 |
AZ9482
PARP inhibitor
|
AZ9482 is a potent PARP inhibitor with IC50 of 1/1/46/9/160/640 nM for PAPR1/PARP2/PARP3/TNKS1/TNKS2/PAPR6 respectively. |
| PC-62698 |
AZ0108
PARP inhibitor
|
AZ0108 is an orally bioavailable phthalazinone PARP inhibitor with enzyme IC50 of <30/<30/83 nM for PARP1/2/6 respectively. |
| PC-61950 |
Simmiparib
PARP1/2 inhibitor
|
Simmiparib is a novel potent, orally active PARP1/2 inhibitor with IC50 of 1.75/0.22 nM, inhibits PARP1 >90-fold more potently than the other PARPs (PARP3, TNKS1, TNKS2). |
| PC-61949 |
Mefuparib hydrochloride
PARP1/2 inhibitor
|
Mefuparib hydrochloride is a potent, highly selective, competitive PARP1/2 inhibitor with IC50 of 3.2/1.9 nM, respectively. |
| PC-61158 |
PARP14 inhibitor H10
|
PARP14 inhibitor H10 (H10) is a potent, selective, cell-active PARP14 inhibitor with IC50 of 490 nM, with good selectivity over other PARPs (24-fold and 18-fold over PARP1 and TNKS1, respectively). |
