| Cat. No. |
Product Name |
Information |
| PC-72149 |
AMXI-5001
PARP inhibitor
|
AMXI-5001 (AMXI 5001) is a novel, highly potent, orally active dual PARP1/2 (IC50 5/0.05 nM) and microtubule polymerization inhibitor, inhibits intracellular PAR formation with IC50 of 7 nM. |
| PC-38102 |
Venadaparib
PARP inhibitor
|
Venadaparib (IDX-1197) is a potent, selective PARP inhibitor with IC50 of 1.4 nM and 1.0 nM for PARP1 and PARP2, respectively. |
| PC-38045 |
DR2313
PARP inhibitor
|
DR2313 is a PARP inhibitor, inhibits poly(ADP-ribosyl)ation in nuclear extracts of rat brain in vitro (Ki=0.23 uM). |
| PC-36037 |
Fluzoparib
PARP inhibitor
|
Fluzoparib (Fuzuloparib, SHR-3162) is a novel, potent and orally available inhibitor of PARP with IC50 of 1.46 nM (PARP1). |
| PC-36012 |
PARP10 inhibitor 22
PARP10 inhibitor
|
PARP10 inhibitor 22 is a selective, cell-active inhibitor of PARP10 with IC50 of 1.8 uM, exhibits >10-fold selectivity over a large subset of other PARP family members. |
| PC-36007 |
MSC2504877
TNKS1/2 inhibitor
|
MSC2504877 (M2912) is a novel small molecule selective tankyrase inhibitor with IC50 of 0.7/0.8 nM against TNKS1/2, shows 771-fold selectivity for TNKS1 over PARP1 (IC50=0.54 uM). |
| PC-35720 |
PARP11 inhibitor ITK7
PARP11 inhibitor
|
PARP11 inhibitor ITK7 (ITK7) is a potent and selective PARP11 inhibitor with IC50 of 14 nM, displays >200-fold selectivity over other PARPs. |
| PC-35703 |
RK-287107
TNKS1/2 inhibitor
|
RK-287107 (RK287107) is a novel potent, tankyrase-specific inhibitor with IC50 of 14.3 and 10.6 nM for tankyrase-1 (TNKS1) and tankyrase-2 (TNKS2) respectively, shows no activity against PARP-1. |
| PC-35646 |
Gemcabene calcium
PARP activator
|
Gemcabene (PD-72953, PD72953) is a first-in-class lipid-lowering agent and activator of PARP. |
| PC-35643 |
Gemcabene
PARP activator
|
Gemcabene (PD-72953, PD72953) is a first-in-class lipid-lowering agent and activator of PARP. |
| PC-35508 |
ME0328
ARTD3/PARP3 inhibitor
|
ME0328 (ME-0328) is a potent, selective inhibitor of ADP-ribosyltransferase ARTD3/PARP3 with IC50 of 0.89 uM. |
| PC-35506 |
ZYTP1
PARP1/2 inhibitor
|
ZYTP1 is a novel, oral PARP inhibitor that inhibits PARP1, PARP2, Tankyrase-1 and Tankyrase-2 with IC50 of 5.4, 0.7, 133.3 and 289.8 nM, respectively. |
