| Cat. No. |
Product Name |
Information |
| PC-45620 |
MN-64
TNKS1 inhibitor
|
MN-64 is a potent and selective inhibitor of Tankyrase 1 (TNKS1) with IC50 of 6 nM. |
| PC-45571 |
NMS-P118
PARP1 inhibitor
|
NMS-P118 is a potent and highly selective PARP-1 inhibitor with Kd of 9 nM; shows 150-fold selectivity for PARP-1 over PARP-2. |
| PC-42269 |
BGP-15
PARP inhibitor, Hsp72 modulator
|
BGP-15 is a PARP inhibitor and an inducer of HSF-1/HSP72 (cotreatment with heat) in vtiro, has no effect on HSP90 levels. |
| PC-45086 |
WIKI4
TNKS2 inhibitor, Wnt/β-catenin inhibitor
|
WIKI4 is a novel small molecule inhibitor of the Wnt/β-catenin pathway by inhibiting the enzymatic activity of TNKS2. |
| PC-42683 |
Niraparib tosylate
PARP1/2 inhibitor
|
Niraparib tosylate (MK-4827) is a highly potent PARP inhibitor with IC50 of 3.8 nM/2.1 nM for PARP1/PARP2. |
| PC-42682 |
MK-4827 hydrochloride
PARP1/2 inhibitor
|
Niraparib (MK-4827) hydrochloride is a highly potent PARP inhibitor with IC50 of 3.8 nM/2.1 nM for PARP1/PARP2. |
| PC-42681 |
Niraparib
PARP inhibitor
|
Niraparib (MK-4827, MK4827) is a highly potent PARP inhibitor with IC50 of 3.8 nM/2.1 nM for PARP1/PARP2. |
| PC-42678 |
A-966492
PARP inhibitor
|
A-966492 (A966492) is a highly potent and efficacious PARP inhibitor with Ki/EC50 of 1 nM/1 nM for PARP-1. |
| PC-27880 |
YCH3292
PARP inhibitor
|
YCH3292 is a potent, new-generation antiresistant PARP inhibitor with IC50 of <0.001 nM for PARP1/2, exhibits robust antiproliferative activity against Capan-1/TP cells with IC50 of 0.23 nM, overcomes acquired resistance to PARPi. |
| PC-27879 |
YCH1899
PARP inhibitor
|
YCH1899 is a potent, new-generation antiresistant PARP inhibitor with IC50 of <0.001 nM for PARP1/2, exhibits antiproliferation activity against olaparib- and talazoparib-resistant cells with IC50 of 0.89 and 1.13 nM, respectively. |
| PC-27584 |
PARP7 inhibitor B-6
PARP7 inhibitor
|
PARP7 inhibitor B-6 is a potent, brain-penetrant PARP7 inhibitor with IC50 of 22.8 nM. |
| PC-26674 |
NU1025
PARP inhibitor
|
NU1025 is a potent PARP inhibitor with IC50 of 400 nM and Ki of 48 nM, potentiates the cytotoxicity of ionizing radiation and anticancer agents, shows anti-cancer and neuroprotective activity. |
