Cat. No. |
Product Name |
Information |
PC-43269 |
AZD8835
PI3Kα/δ inhibitor
|
AZD8835 (AZD-8835) is a potent, selective inhibitor of PI3Kα and PI3Kδ with IC50 of 6.2 and 5.7 nM, 15-fold and >100-fold selectivity over PI3Kγ and PI3Kβ. |
PC-43268 |
PQR309
PI3K/mTOR inhibitor
|
PQR309 (Bimiralisib) is a potent, brain-penetrant, orally bioavailable, pan-class I PI3K/mTOR inhibitor with IC50 of 33, 451, 661, 708 and 89 nM for PI3Kα, PI3Kδ, PI3Kβ, PI3Kγ and mTOR, respectively. |
PC-43214 |
Vps34-IN-1
Vps34 inhibitor
|
Vps34-IN-1 is a potent, selective inhibitor of class III PI3K Vps34 with IC50 of 25 nM, does not inhibit class I and II PI3Ks, as well as a broad panel of protein kinases or lipid kinases. |
PC-43213 |
Vps34 inhibitor PIK-III
Vps34 inhibitor
|
Vps34 inhibitor PIK-III (PIK-III) is a potent, selective inhibitor of Vps34 with IC50 of 18 nM, shows >100-fold selectivity over other class I PI3Ks, PI4Kβ and mTOR. |
PC-43188 |
GNE-317
PI3K/mTOR inhibitor
|
GNE-317 (GNE317) is a potent, brain penepenetrant, dual PI3K/mTOR inhibitor having physicochemical properties predictive of low efflux by P-gp and BCRP. |
PC-43131 |
Acalisib
p110δ inhibitor
|
Acalisib (GS-9820, CAL-120) is a potent, isoform-selective PI3K p110δ with IC50 of 12.7 nM, displays >100-fold selectivity over P110α/β/γ, and other class II/III PI3Ks, DNA-PK, mTOR. |
PC-43082 |
LY3023414
PI3K/mTOR inhibitor
|
LY3023414 is a potent, dual PI3K/mTOR inhibitor with IC50 of 6.07 nM, 77.6 nM, 38 nM, 23.8 nM, 165 nM and 4.24 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ, mTOR and DNA-PK, respectively. |
PC-43055 |
SAR405
Vps34 inhibitor
|
SAR405 is a highly potent and selective PI3K class III isoform Vps34 inhibitor with IC50 of 1.2 nM, inhibits the formation of autophagosomes in GFP-LC3 cells with IC50 of 4 nM. |
PC-42989 |
ETP-46321
PI3K α/δ inhibitor
|
ETP-46321 is a potent, selective, orally bioavailable dual PI3K α/δ inhibitor with IC50 of 2.3/14.2 nM, weakly inhibits p110β and p110γ with IC50 of 170 and 179 nM. |
PC-42987 |
ON 146040
PI3K/BCR-ABL inhibitor
|
ON 146040 is a potent, dual PI3K/BCR-ABL inhibitor with IC50 of 14/20 nM for PI3Kα/δ , IC50 of 20 nM for BCR/ABL. |
PC-42978 |
AZD8186
PI3Kβ inhibitor
|
AZD8186 is a potent, isoform-specific PI3Kβ inhibitor with IC50 of 4 nM, also inhibits PI3Kδ (IC50=12 nM) with selectivity over PI3Kα (IC50=35 nM) and PI3Kγ (IC50=675 nM). |
PC-42947 |
MLN1117
p110α inhibitor
|
MLN1117 (INK1117,TAK-117, Serabelisib) is a potent, selective PI3K p110α inhibitor with IC50 of 15 nM, displays >300-fold selectivity over p110β/γ/δ and mTOR. |