| Cat. No. |
Product Name |
Information |
| PC-42850 |
GSK1059615
PI3K/mTOR inhibitor
|
GSK1059615 is a highly potent, dual PI3K/mTOR inhibitor with IC50 of 0.4 nM/0.6 nM/2 nM/5 nM and 12 nM for PI3Kα/β/δ/γ and mTOR, respectively. |
| PC-42844 |
PIK-90
DNA-PK/PI3K inhibitor
|
PIK-90 is a potent DNA-PK and PI3K inhibitor that inhibits p110α, p110γ and DNA-PK with IC50s of 11, 18 and 13 nM, respectively. |
| PC-42812 |
PI3K inhibitor X
class I PI3K inhibitor
|
PI3K inhibitor X (XL-147 analog) is a derivative of XL147 that acts as a reversible inhibitor of class I PI3Ks with IC50 of 39, 36, 23 and 383 nM for p110α, δ, γ and β respectively. |
| PC-63185 |
AS2541019
PI3Kδ inhibitor
|
AS2541019 is a novel potent, selective, orally active PI3Kδ inhibitor with IC50 of 20.1 nM, >100-fold selectivity over other PI3K isoforms. |
| PC-63013 |
GNE-490
PI3K inhibitor
|
GNE-490 is a potent, selective, orally available class I PI3K inhibitor with IC50 of 3.5/25/5.2/15 nM for PI3Kα/PI3Kβ/PI3Kγ/PI3Kδ. |
| PC-62886 |
GNE-293
PI3Kδ inhibitor
|
GNE-293 is a potent and selective PI3Kδ inhibitor with Ki of 0.47 nM, displays 256, 420, 219-fold selectivity over PI3Kα, PI3Kβ, PI3Kγ, respectively. |
| PC-62843 |
PI3Kα-IN-4h
PI3Kα inhibitor
|
PI3Kα-IN-4h is a potent, selective, ATP-competitive dual PI3Kα/mTOR inhibitor with IC50 of 0.5/104 nM respectively. |
| PC-62838 |
PI3Kα-IN-5
PI3Kα inhibitor
|
PI3Kα-IN-5 is a potent, selective PI3Kα inhibitor with enzyme IC50 and cell IC50 of 6 nM and 87 nM respectively, exhibits 100-fold selectivity over PI3Kβ. |
| PC-62830 |
PI3K-IN-8q
p110α/p110δ inhibitor
|
PI3K-IN-8q is a potent, selective dual p110α/p110δ inhibitor with Ki app of 3.3/8.36 nM respectively. |
| PC-62806 |
PI3Kδ-IN-7n
PI3Kδ inhibitor
|
PI3Kδ-IN-7n is a highly potent and selective PI3Kδ inhibitor with IC50 of 0.9 nM, displays high selectivity (>1,500-fold) over PI3Kα, PI3Kβ, PI3Kγ (IC50>1.5 uM). |
| PC-62708 |
PI3K-IN-16
PI3Kβ/δ inhibitor
|
PI3K-IN-16 is a potent and selective, orally bioavailable PI3Kβ and PI3Kδ inhibitor with cell IC50 of 12 nM (in PTEN null MDA-MB-468 cell) and 47 nM (in Jeko-1 B-cell), respectively. |
| PC-61959 |
DS-7423
PI3K/mTOR inhibitor
|
DS-7423 is a novel potent, small-molecule dual inhibitor of PI3K/mTOR with IC50 of 15.6, 1143, 249, 262 and 34.9 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ, and mTOR respectively. |
