| Cat. No. |
Product Name |
Information |
| PC-61742 |
ST-162
MAPK/PI3K inhibitor
|
ST-162 is a potent, bifunctional MAPK/PI3K antagonist with IC50 of 191 nM and 398 nM for PI3Kα and MEK1, respectively. |
| PC-61741 |
ST-168
MEK/PI3K inhibitor
|
ST-168 is a novel potent, orally available MEK/PI3K bifunctional inhibitor with IC50 of 182, 69.2, 1482, 2293, and 41.7 nM for MEK1, PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ, respectively. |
| PC-61135 |
PI3Kβ/δ inhibitor 20a
PI3Kβ/δ inhibitor
|
PI3Kβ/δ inhibitor 20a is a potent, highly selective PI3Kβ/δ inhibitor with IC50 of 7.8/5.3 nM respectively, with liitle to no activity on PI3Kα/γ (IC50=850/>10,000 nM). |
| PC-61127 |
PI3Kδ inhibitor 52
|
ZUN64390 is a potent, selective, and efficacious PI3Kδ inhibitor with IC50 of 1.7 nM, >100-fold selectivitity over PI3Kγ/α/β. |
| PC-60983 |
AMG511
PI3K inhibitor
|
AMG511 (AMG-511) potent, efficacious, and orally available pan class I PI3K inhibitor with Ki of 4/6/2/1 nM for PI3Kα/β/δ/γ, respectively. |
| PC-60567 |
Tenalisib
p110δ/γ inhibitor
|
Tenalisib (RP6530) is a potent, selective, orally active p110δ/γ PI3K dual inhibitor with IC50 of 24.5 and 33.2 nM, respectively. |
| PC-60566 |
IPI-443
p110δ/γ inhibitor
|
A potent, selective, orally active p110δ/γ PI3K dual inhibitor with cellular IC50 of 0.29 and 7.1 nM, respectively. |
| PC-60565 |
IPI-3063
p110δ inhibitor
|
IPI-3063 is apotent, and selective p110δ PI3K inhibitor with IC50 of 0.1 nM in cell-based assays. |
| PC-60527 |
Parsaclisib
PI3Kδ inhibitor
|
Parsaclisib (INCB050465) is a potent and highly selective PI3Kδ inhibitor with IC50 of < 1 nM (SPA). |
| PC-60447 |
LAS191954
PI3Kδ inhibitor
|
LAS191954 is a potent, selective, orally bioavailable PI3Kδ inhibitor with IC50 of 2.6 nM. |
| PC-60413 |
SF-1126
|
SF-1126 is a pan PI3K/BRD4 inhibitor, RGDS-conjugated LY294002 prodrug that exhibits increased solubility and binds to specific integrins. |
| PC-60392 |
SN32976
PI3K/mTOR inhibitor
|
SN32976 is a novel, potent and selective class I PI3K and mTOR inhibitor with IC50 of 15.1/461/110/134/194 nM for PI3Kα/PI3Kβ/PI3Kγ/PI3Kδ/mTOR, respectively. |
