| Cat. No. |
Product Name |
Information |
| PC-49022 |
PF-06862309
PI3Kα inhibitor
|
PF-06862309 (PF-06843195 phosphate ester prodrug) is the in vivo-active, phosphate ester prodrug of PF-06843195, a potent selective PI3Kα inhibitor with Kd of <18 pM. |
| PC-49021 |
PF-06843195
PI3Kα inhibitor
|
PF-06843195 is a potent, selective PI3Kα inhibitor with Ki value of <0.018 nM, IC50 of 18 nM (RAT1 PI3Kα), with cellular isoform selectivity of 20-fold over PI3Kβ and 9-fold over PI3Kδ. |
| PC-38789 |
LL-00071210
PI3Kδ inhibitor
|
LL-00071210 is a potent, selective, orally bioavailable PI3Kδ inhibitor with IC50 values of 24.6 nM and 9.4 nM in biochemical and cellular assays, respectively. |
| PC-38687 |
HM5023507
PI3Kδ/γ inhibitor
|
HM5023507 is a potemt, selective, orally active dual PI3Kδ/γ inhibitor with IC50 of 4 nM and 5 nM for p110γ and p110δ, respectively. |
| PC-38686 |
AZD8154
PI3Kδ/γ inhibitor
|
AZD8154 is a highly potent, selective dual PI3Kγ/δ inhibitor with cell pIC50 of 9.1/8.4, respectively. |
| PC-38635 |
NVP-CLR457
class I PI3K inhibitor
|
NVP-CLR457 (CLR457) is a potent, orally bioavailable, non-CNS-penetrant pan-class I PI3K inhibitor with IC50 values of 89 nM, 56 nM, 39 nM and 230 nM for p110α, p110β, p110δ and p110γ isoforms, respectively. |
| PC-38383 |
Amdizalisib
PI3Kδ inhibitor
|
Amdizalisib (HMPL-689) is a highly selective and potent oral inhibitor of phosphoinositide 3-kinase-delta (PI3Kδ) with potential antineoplastic activity. |
| PC-73424 |
Izorlisib
PI3K inhibitor
|
Izorlisib (MEN1611, CH5132799) is a potent, selective, orally available class I PI3K inhibitor with IC50 of 14/120/400/36 nM against PI3Kα/β/δ/γ, respectively. |
| PC-73420 |
Gilmelisib
PI3K inhibitor
|
Gilmelisib is a potent PI3K inhibitor with IC50 of <1 nM for PI3K p110α, exhibits antineoplastic acitvity. |
| PC-73277 |
PQR514
PI3K inhibitor
|
PQR514 is a potent selective pan-PI3K inhibitor with binding Ki of 2.2 and 33 nM for p110α and mTOR, repectively. |
| PC-72781 |
GSK251
PI3Kδ inhibitor
|
GSK251 is a highly potent, selective, orally bioavailable inhibitor of PI3Kδ with pKi of 10.9, >1,000-fold selectivity over other PI3K isoforms. |
| PC-72075 |
FAPL-PI3Ki1
FAP-targeted PI3K inhibitor
|
FAPL-PI3Ki1 is a specific FAP-targeted PI3K inhibitor that selectively targets FAP-expressing human IPF lung fibroblasts and potently inhibits collagen synthesis. |
