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Cat. No. Product Name Information
PC-21944

GSK2636771

PI3Kβ inhibitor

GSK2636771 is a potent, selective and orally bioavailable inhibitor of PI3Kβ with Ki/IC50 of 0.89/5.2 nM, respectively.
PC-20590

Alpelisib

PI3Kα inhibitor

Alpelisib (NVP-BYL719, BYL719) is ia potent, selective, and orally active PI3Kα inhibitor with IC50 of 5 nM, >50-fold selectivity over p110γ/p110δ/p110β.
PC-20568

Zandelisib

p110δ inhibitor

Zandelisib (ME-401, PWT-143) is a potent, selective and orally active inhibitor of phosphatidylinositol 3 kinase p110δ with IC50 of 3.5 nM.
PC-20534

Copanlisib

PI3K inhibitor

Copanlisib (BAY 80-6946) is a potent, highly selective pan-class I PI3K inhibitor with IC50 of 0.5, 3.7, 6.4, and 0.7 nM for PI3Kα, β, γ, and δ isoforms, respectively.
PC-20468

PI3Kβ inhibitor (P)-14

PI3Kβ inhibitor (P)-14 is a potent, highly selective and orally bioavailable PI3Kβ inhibitor with IC50 of 2 nM.
PC-20453

TGX286

p110β inhibitor

TGX286 is a potent, selective p110β inhibitor with IC50 of 7, 17 and 13 nM for p110β WT, p110β D862Q, and p110β E858H, respectively, >100-fold selectivity over p110α.
PC-20451

PITCOIN2

PI3KC2α inhibitor

PITCOIN2 (LU-06-006) is a potent selective PI3KC2α inhibitor with IC50 of 126 nM, has selectivity against PI3KC2γ but shows micromolar activity on PI3KC2β.
PC-20375

VPS34 inhibitor 5

VPS34 inhibitor 5 is a potent, selective, and orally bioavailable VPS34 inhibitor with IC50 of 83 nM, >95-fold selectivity over other PIK family kinases.
PC-20374

I-229

Vps34 inhibitor

I-229 is a potent and selective inhibitor of Vps34.
PC-20008

cyclo-CRVLIR

p110α/RAS inhibitor

cyclo-CRVLIR is a cyclic peptide that binds selectively to p110α RAS binding domain (p110α-RBD) with ITC Kd of 3 uM, blocks p110α/RAS interaction in vitro and KRAS cancer cell lines.
PC-49266

LP-182

PI3K inhibitor

LP-182 (LP182) is a potent, selective and orally bioavailable multi-functional kinase inhibitor, specifically targets PI3K and MAPK signaling pathways.
PC-38789

LL-00071210

PI3Kδ inhibitor

LL-00071210 is a potent, selective, orally bioavailable PI3Kδ inhibitor with IC50 values of 24.6 nM and 9.4 nM in biochemical and cellular assays, respectively.

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