| Cat. No. |
Product Name |
Information |
| PC-20568 |
Zandelisib
p110δ inhibitor
|
Zandelisib (ME-401, PWT-143) is a potent, selective and orally active inhibitor of phosphatidylinositol 3 kinase (PI3K) p110δ with IC50 of 3.5 nM. |
| PC-20534 |
Copanlisib
PI3K inhibitor
|
Copanlisib (BAY 80-6946) is a potent, highly selective pan-class I PI3K inhibitor with IC50 of 0.5, 3.7, 6.4, and 0.7 nM for PI3Kα, β, γ, and δ isoforms, respectively. |
| PC-20468 |
PI3Kβ inhibitor (P)-14
PI3Kβ inhibitor
|
PI3Kβ inhibitor (P)-14 is a potent, highly selective and orally bioavailable PI3Kβ inhibitor with IC50 of 2 nM. |
| PC-20453 |
TGX286
p110β inhibitor
|
TGX286 is a potent, selective p110β inhibitor with IC50 of 7, 17 and 13 nM for p110β WT, p110β D862Q, and p110β E858H, respectively, >100-fold selectivity over p110α. |
| PC-20451 |
PITCOIN2
PI3KC2α inhibitor
|
PITCOIN2 (LU-06-006) is a potent selective PI3KC2α inhibitor with IC50 of 126 nM, has selectivity against PI3KC2γ but shows micromolar activity on PI3KC2β. |
| PC-20375 |
VPS34 inhibitor 5
Vps34 inhibitor
|
VPS34 inhibitor 5 is a potent, selective, and orally bioavailable VPS34 inhibitor with IC50 of 83 nM, >95-fold selectivity over other PIK family kinases. |
| PC-20374 |
I-229
Vps34 inhibitor
|
I-229 is a potent and selective inhibitor of Vps34. |
| PC-20008 |
cyclo-CRVLIR
p110α/RAS inhibitor
|
cyclo-CRVLIR is a cyclic peptide that binds selectively to p110α RAS binding domain (p110α-RBD) with ITC Kd of 3 uM, blocks p110α/RAS interaction in vitro and KRAS cancer cell lines. |
| PC-49531 |
LL-00084282
PI3Kδ/γ inhibitor
|
LL-00084282 is a potent, selective and efficacious dual PI3Kδγ inhibitor with IC50 of 16.26 and 17.45 nM for PI3Kδ and PI3Kγ, respectively. |
| PC-49341 |
PITCOIN3
PI3KC2α inhibitor
|
PITCOIN3 is a potent, highly selective, cell-permeable inhibitor of PI3KC2α catalytic activity with IC50 of 126 nM. |
| PC-49266 |
LP-182
PI3K inhibitor
|
LP-182 (LP182) is a potent, selective and orally bioavailable multi-functional kinase inhibitor, specifically targets PI3K and MAPK signaling pathways. |
| PC-49141 |
CUDC-907
HDAC/PI3K inhibitor
|
Fimepinostat (CUDC-907) is a potent, dual-acting PI3K and HDAC inhibitor, potently inhibits HDAC classes I and II enzymes, inhibits class I PI3K kinases with IC50 of 19, 54, and 39 nM for PI3Kα, PI3Kβ, and PI3Kδ, respectively. |
