| Cat. No. |
Product Name |
Information |
| PC-61592 |
IVA-337
|
IVA-337 (Lanifibranor, IVA337)) is a potent, pan PPAR agonist with EC50 of 0.92 uM, 0.53 uM and 0.18 uM for human PPARα, PPARδ and PPARγ respectively. |
| PC-61150 |
Seladelpar
PPARδ agonist
|
Seladelpar (MBX-8025) is a potent, selective, orally bioavailable PPAR-delta (PPARδ) agonist with EC50 of 2 nM, displays >750-fold selective over PPAR-α. |
| PC-60334 |
UHC1
PPARγ ligand
|
UHC1 is a potent, non-agonist PPARγ ligand that blocks CDK5-mediated PPARγ phosphorylation, without the classical agonism. |
| PC-45121 |
WY-14643
PPARα agonist
|
A potent, selective PPARα agonist with EC50 of 0.63 uM. |
| PC-45390 |
Pemafibrate
PPARα agonist
|
Pemafibrate (K-877) is a highly potent, specific PPARα agonist with EC50 of 1 nM. |
| PC-22207 |
E09241
Osteoprotegerin upregulator, PPARδ activator
|
E09241 is a small molecule osteoprotegerin (OPG) upregulator with EC50 of 1.23 uM, effectively promotes osteogenesis and inhibits osteoclastogenesis through activating the PPARδ signaling pathway. |
| PC-22205 |
E0924G
Osteoprotegerin upregulator, PPARδ activator
|
E0924G is a small molecule osteoprotegerin (OPG, EC50=0.29 uM) and runt-related transcription factor 2 (RUNX2) upregulator, effectively promotes osteogenesis and inhibits osteoclastogenesis through activating the PPARδ signaling pathway. |
| PC-20679 |
FTX-6746
PPARγ inhibitor
|
FTX-6746 (FTX6746) is a potent, highly selective and orally active proliferator-activated receptor gamma (PPARG, PPARγ) inhibitor with cellular IC50 of 5 nM, >100-fold selectivity over PPARD and PPARA. |
| PC-20667 |
FX-909
PPARγ inhibitor
|
FX-909 (FX909) is a potent, selective and covalent peroxisome proliferator-activated receptor gamma (PPARG, PPARγ) inhibitor with cellular IC50 of 1 nM, >2000-fold selective over PPARα/PPARδ. |
| PC-20276 |
GSK3787
PPARδ antagonist
|
GSK3787 (GSK 3787) is a potent, selective and irreversible antagonist of PPARdelta (PPARδ) with binding pIC50 of 6.6, without measurable affinity for hPPARα or hPPARγ. |
| PC-49399 |
BAY-4931
PPARγ inverse agonist
|
BAY-4931 (BAY4931) is a potent, selective, covalent PPARγ inverse agonist with IC50 of 0.17 nM in cellular reporter assays. |
| PC-49255 |
Leriglitazone
PPARγ agonist
|
MIN-102 (Leriglitazone) is a novel brain penetrant, selective and orally bioavailable PPARγ agonist with a potential best-in-class profile indicated for CNS diseases. |
