| Cat. No. |
Product Name |
Information |
| PC-26313 |
SIP0401
PDE4B inhibitor
|
SIP0401 is a potent, isoform-preferential PDE4B inhibitor with IC50 of 282 nM (PDE-Glo) and 338.4 nM (HTRF), selective for PDE4B over PDE4A/C/D (IC50=1.16-1.97 uM). |
| PC-26218 |
DC591017
PDE4 inhibitor
|
DC591017 is a novel potent PDE4 inhibitor with IC50 of 0.24 uM (PDE4D), highly selective for PDE4 vs PDE1, 2, 5-9, and PDE11 and exhibits at >4-fold selectivity over PDE3 and PDE10. |
| PC-25902 |
NSP-513
PDE3 inhibitor
|
NSP-513 is a potent and selective phosphodiesterase 3 (PDE 3) inhibitor, shows antiplatelet, antithrombotic, and hemodynamic effects. |
| PC-25901 |
Cilostamide
PDE3 inhibitor
|
Cilostamide (OPC3689) is a potent, selective PDE3 inhibitorwith IC50 of 27 nM and 50 nM for PDE3A and PDE3B, respectively, shows antithrombotic and anti-intimal hyperplastic activity. |
| PC-25900 |
Milrinone
PDE3 inhibitor
|
Milrinone (Win 47203) is a potent, selective PDE3 inhibitor with IC50 of 280 nM and 440 nM for PDE3B and PDE3A respectively. |
| PC-25899 |
PDE3B inhibitor 18f
PDE3B inhibitor
|
PDE3B inhibitor 18f (PDE3B-IN-3) is a potent, subtype selective PDE3B inhibitor with IC50 of 4.5 nM, >30-fold selective over PDE3A (IC50=150 nM). |
| PC-25898 |
PDE3B inhibitor 8a
PDE3B inhibitor
|
PDE3B inhibitor 8a (PDE3B-IN-2) is a potent, subtype selective, orally active PDE3B inhibitor with IC50 of 0.19 nM and 1.3 nM for PDE3B and PDE3A respectively. |
| PC-25897 |
PDE3B inhibitor 18
PDE3B inhibitor
|
PDE3B inhibitor 18 (PDE3B-IN-1) is a selective PDE3B inhibitor with pIC50 of 6.5, >300-fold selective over PDE3A. |
| PC-25896 |
GSK4394835A
PDE3B inhibitor
|
GSK4394835A is a selective PDE3B inhibitor with pIC50 of 6.2, >20-fold selective over PDE3A. |
| PC-25743 |
Icariin
PDE5 inhibitor, PPARα activator
|
Icariin is a flavonol glycoside that inhibits PDE5 and PDE4 activities with IC50 of 432 nM and 73.50 μM, respectively, also is a PPARα activator, also is a small-molecule inducer that promotes G3BP1-driven biomolecular condensate formation, interacts with the N-terminal nuclear transport factor 2-like (NTF2L) domain of G3BP1. |
| PC-25667 |
Zardaverine
PDE3/4 inhibitor
|
Zardaverinea is a potent, specific PDE III/IV (PDE3/4) inhibitor, inhibits PDE III from human platelets and the rolipram-inhibitable PDE IV from canine trachea and human polymorphonuclear (PMN) cells with IC50 of 0.58, 0.79 and 0.17uM, respectively. |
| PC-25665 |
Nauclefine
PDE3A-SLFN12 inducer
|
Nauclefine is an indole alkaloid natural productthat binds PDE3A but does not inhibit the PDE3A's phosphodiesterase activity, induces apoptosis of diverse cancer cells via a PDE3A-SLFN12 dependent death pathway. |
