| Cat. No. |
Product Name |
Information |
| PC-62885 |
(R)-DNMDP
|
(R)-DNMDP (DNMDP R-form) is the R-form of is DNMDP, which is a potent and selective cancer cell cytotoxic agent that binds to PDE3A, promotes an interaction between PDE3A and Schlafen 12 (SLFN12).. |
| PC-62884 |
Trequinsin hydrochloride
|
Trequinsin hydrochloride (HL 725) is a potent, cell-permeable, orally active inhibitor of cGMP-inhibited phosphodiesterase (PCE3 IC50=250 pM), inhibits arachidonic acid-induced aggregation of human platelets with IC50 of 50 pM. |
| PC-62737 |
PDE10A-IN-31
|
PDE10A-IN-31 is a potent, highly selective PDE10A inhibitor with IC50 of 2 nM for both rPDE10A and hPDE10A. |
| PC-62700 |
PyP-1
|
PyP-1 is a potent, highly selective, and orally bioavailable PDE10A inhibitor with Ki of 0.23 nM. |
| PC-61897 |
UK-369003
|
UK-369003 (Gisadenafil besylate) is a novel, potent, selective, orally bioavailable PDE5 inhibitor with IC50 of 1.23 nM, displays 117-fold selectivity over PDE6. |
| PC-61858 |
PF-03049423
|
PF-03049423 is a potent, selective, orally active, and brain penetrant inhibitor of PDE5 with IC50 of 0.2 nM. |
| PC-61617 |
GSK-256066
|
GSK-256066 is a highly potent, selective PDE4B inhibitor with pIC50 of 11.1, apparent IC50 of 3.2 pM, inhibits PDE4 isoforms A-D with equal affinity. |
| PC-61348 |
PQ-10
|
A potent, selective, brain penetrant PDE10A inhibitor with Ki of 4 nM. |
| PC-61346 |
BMS 843496
|
A potent and selective PDE10A inhibitor with binding affinity (Kd) of 0.15 nM, IC50 of 2.11 nM. |
| PC-61344 |
MY-5445
|
A specific PDE5 inhibitor that inhibits human platelet aggregation induced by 3 uM ADP, 3 mg/ml of collagen and 100 ug/ml of arachidonic acid with IC50 of 0.07, 0.02 and 0.17 uM, respectively. |
| PC-61343 |
Lu AF-58027
|
A novel potent, selective PDE1 inhibitor with IC50 of 13/45/1.4 nM for PDE1A/B/C, respectively. |
| PC-61342 |
PF-04471141 hydrochloride
|
A potent and selective, CNS-penetrant PDE1 inhibitor with IC50 of 35 nM for PDE1B.. |
