| Cat. No. |
Product Name |
Information |
| PC-21464 |
ME3183
PDE4 inhibitor
|
ME3183 is a potent, selective phosphodiesterase 4 (PDE4) inhibitor with IC50 of 2.33, 1.28 and 1.63 nM for PDE4B1, PDE4A1A and PDE4D2 respectively. |
| PC-21270 |
PDE11A4 inhibitor 23b
PDE11A4 inhibitor
|
PDE11A4 inhibitor 23b is a potent, selective PDE11A4 inhibitor with IC50 of 12 nM. |
| PC-20981 |
PDE12 inhibitor Compound 1
PDE12 inhibitor
|
PDE12 inhibitor Compound 1 is a potent, selective inhibitor of phosphodiesterase 12 (PDE12) with pIC50 of 9.1 and Ki of 17.5 nM, >1000-fold selectivity over EEP nuclease family member CNOT6. |
| PC-20974 |
CC-11050
PDE4 inhibitor
|
Dovramilast (CC-11050) is a potent and orally active phosphodiesterase 4 (PDE4) inhibitor, CC-11050 is a promising candidate for host directed therapy of patients with pulmonary TB. |
| PC-20916 |
Sildenafil
PDE5 inhibitor
|
Sildenafil (UK-92480) is a potent, selective, orally active phosphodiesterase type 5 (PDE5) inhibitor with IC50 of 3.9 nM. |
| PC-20682 |
PF-07038124
PDE4 inhibitor
|
PF-07038124 (PF 07038124) is a highly potent, selective PDE4 inhibitor with IC50 of 0.5 nM for PDE4B2 in SPA assays, inhibits cytokines release of IL-4, IL-13 and IFNy from human PBMCs stimulated with PHA-L with IC50 of 135, 4.1, and 1.06 nM, respectively. |
| PC-20681 |
Roflumilast
PDE4 inhibitor
|
Roflumilast (APTA-2217) is a potent, selective, orally active PDE4 inhibitor with IC50 of 0.7, 0.9, 0.7, and 0.2 nM for PDE4A1, PDEA4, PDEB1, and PDEB2, respectively. |
| PC-20471 |
PDE4 inhibitor Compound A
|
PDE4 inhibitor Compound A is a potent, highly selective PDE4 inhibitor with IC50 of 1.1 nM (PDE4B2), weakly inhibits PDE3 (IC50=150 nM) and does not inhibit other PDE subtypes. |
| PC-20038 |
Gemlapodect
PDE10A inhibitor
|
Gemlapodect (NOE-105) is a potent, selective PDE10A inhibitor with a potential therapeutic effect for the treatment of COFD. |
| PC-49573 |
CRD733
PDE9A inhibitor
|
CRD733 (ASP4901) is a potent, selective cGMP-specific PDE9 (phosphodiesterase 9) inhibitor. |
| PC-49572 |
BAY-7081
PDE9A inhibitor
|
BAY-7801 (BAY7801) is a potent, selective, and orally bioavailable PDE9A inhibitor with IC50 of 15 nM (human PDE9A), 49-fold selectivity over PDE1. |
| PC-49494 |
MK-8189
PDE10A inhibitor
|
MK-8189 (MK8189) is a highly potent, selective PDE10A inhibitor with Ki of 29 pM, 500,000-fold selectivity over the other PDE enzyme families (PDE1-PDE11). |
