| Cat. No. |
Product Name |
Information |
| PC-49420 |
MCI-030
PDE10 inhibitor
|
MCI-030 (ADT 061) is a potent, selective PDE10 inhibitor, inhibits recombinant PDE10 using cGMP as a substrate with IC50 of 0.3 uM. |
| PC-49288 |
TPN171
PDE5 inhibitor
|
TPN171 (TPN-171) is a highly potent, selective phosphodiesterase type 5 (PDE5) inhibitor with IC50 of 0.62 nM, 32-fold selectivity over PDE6. |
| PC-38810 |
Yonkenafil
PDE5 inhibitor
|
Yonkenafil is a potent, selective PDE5 inhibitor with IC50 of 2.0 nM. |
| PC-38701 |
PF-04957325
PDE8 inhibitor
|
PF-04957325 is a highly potent and selective PDE8 inhibitor with IC50 values of 0.7 nM and 0.3 nM for PDE8A and PDE8B, respectively. |
| PC-38401 |
Irsenontrine
PDE9 inhibitor
|
Irsenontrine (E2027) is a potent, selective and orally active phosphodiesterase 9 (PDE9) inhibitor, reduces the degradation of cyclic GMP (cGMP) which is critical to signal transmission among cells, and helps maintain the concentration of cGMP in the brain. |
| PC-73431 |
Mufemilast
PDE4 inhibitor
|
Mufemilast (Hemay005) is a potent, selective, first-in-class PDE4 inhibitor with in vitro IC50 of 80-120 nM, exhibits comparable inhibitory activities to apremilast. |
| PC-73315 |
DNMDP
PDE3A-SLFN12 inducer
|
DNMDP is a small molecule that induces complex formation between phosphodiesterase 3A (PDE3A) and schlafen family member 12 (SLFN12), specifically kills cancer cells with high levels of PDE3A and SLFN12 expression. |
| PC-72340 |
LY2775240
PDE4 inhibitor
|
LY2775240 (LY-2775240) is a highly selective, potent and orally active inhibitor of phosphodiesterase 4 (PDE4) with IC50 of 0.09/0.09/2.4/0.14 nM for PDE4A/B/C/D. |
| PC-72172 |
IMR-687
PDE9 inhibitor
|
IMR-687 (IMR687, Tovinontrine) is a novel, potent and selective phosphodiesterase-9 (PDE-9) inhibitor with IC50 of 8.19 nM and 9.99 nM against PDE9A1 and PDE9A2, respectively. |
| PC-35839 |
PDE2 inhibitor 4
|
PDE2 inhibitor 4 is a potent, selective, orally available inhibitor of PDE2 with IC50 of 2 nM, displays high selectivity versus other PDE isoforms. |
| PC-63306 |
PDE10A-IN-32
|
PDE10A-IN-32 is a potent, highly selective, brain penetrant PDE10A inhibitor with IC50 of 0.14 nM, displays no significant activity against other PDEs (IC50>1,000 nM).. |
| PC-63121 |
PDE4D-IN-26b
|
PDE4D-IN-26b is a potent, highly selective PDE4D inhibitor with IC50 of 0.6 nM, displays 75-fold lower activity against the PDE4A, B, and C subtypes, also exhibits 18,000-fold decreased potency against other PDE family members. |
