| Cat. No. |
Product Name |
Information |
| PC-63094 |
Oglemilast
PDE4 inhibitor
|
Oglemilast (GRC-3886) is a potent and selective PDE4 inhibitor with IC50 of 2.5 and 1.7 nM for PDE4B and PDE4D, respectively.. |
| PC-63093 |
Tetomilast
PDE4 inhibitor
|
Tetomilast (OPC-6535) is a superoxide anion production inhibitor that inhibits PDE4 and proinflammatory functions of leukocytes including superoxide production and cytokine release. |
| PC-63092 |
Filaminast
PDE4 inhibitor
|
Filaminast (WAY-PDA-641, PDA-641, WAY-123641) is a potent and selective PDE4 inhibitor with IC50 of 420 nM, displays 36-fold selectivity over PDE3. |
| PC-63091 |
Lirimilast
PDE4 inhibitor
|
Lirimilast (BAY19-8004, BAY 198004) is a potent and selective PDE4 inhibitor with IC50 of 49 nM, shows potential for the treatment of COPD. |
| PC-63090 |
Tofimilast
PDE4 inhibitor
|
Tofimilast (CP-325366) is a potent, selective PDE4 inhibitor with IC50 of 23, 13 and 13 nM for PDE4A, PDE4B, and PDE4D, respectively. |
| PC-63089 |
Piclamilast
PDE4 inhibitor
|
Piclamilast (RP-73401) is a potent and highly selective PDE4 inhibitor with IC50 of 1.2 nM. |
| PC-63088 |
HT-0712
PDE4 inhibitor
|
HT-0712 (IPL-455903) is a novel potent, selective PDE4 inhibitor with IC50 of 0.15 uM for PDE4D3, without effect on PDE1B, PDE3A, and PDE10A. |
| PC-63029 |
TPN729 maleate
PDE5 inhibitor
|
TPN729 maleate is a novel potent, selective phosphodiesterase type 5 (PDE5) inhibitor with IC50 of 2.28 nM. |
| PC-63028 |
TPN729
PDE5 inhibitor
|
TPN729 is a novel potent, selective phosphodiesterase type 5 (PDE5) inhibitor with IC50 of 2.28 nM, shows better selectivity profile 2.5 times higher than sildenafil against PDE6 and 500 times higher than tadalafil against PDE11. |
| PC-62973 |
FCPR03
PDE4 inhibitor
|
FCPR03 is a novel potent, selective PDE4 inhibitor with IC50 of 60, 31 and 47 nM for PDE4CAT (PDE4 catalytic domain), PDE4B1 and PDE4D7, respectively. |
| PC-62897 |
CI-1044
PDE4 inhibitor
|
CI-1044 is a potent, selective and orally bioavailable PDE4 inhibitor with IC50 of 0.27 uM, displays high selectivity for PDE4 versus PDE1/3/5, and no PDE4 subtype (4A-D) selectivities. |
| PC-62528 |
PF-06815189
PDE2 inhibitor
|
PF-06815189 is a potent, selective phosphodiesterase 2 (PDE2) inhibitor with IC50 of 0.4 nM, >1,000-fold selectivity over PDE5. |
