| Cat. No. |
Product Name |
Information |
| PC-70272 |
Zaprinast
PDE5/6 inhibitor, GPR35 agonist
|
Zaprinast (M&B 22948) is a potent, cGMP-specific phosphodiesterase inhibitor with IC50 of 0.5-0.76 and 0.15 uM for PDE5 and PDE6 respectively, also is an agonist for GPR35 (EC50=16/840 nM for rat/human GPR35). |
| PC-60996 |
ASP9436
PDE10A inhibitor
|
ASP9436 (ASP-9436) is a potent, selective brain penetrant and orally active phosphodiesterase 10A (PDE10A) inhibitor with IC50 of 8.0 nM, >420-fold selectivity over other PDE subtypes. |
| PC-60796 |
JNJ-42314415
PDE10A inhibitor
|
JNJ-42314415(JNJ42314415) is a potent, selective, centrally active phosphodiesterase 10A (PDE10A) inhibitor with Ki of 35 nM for human recombinant PDE10A. |
| PC-60725 |
CHF6001
PDE4 inhibitor
|
Tanimilast (CHF6001) is a novel, highly potent and selective phosphodiesterase 4 (PDE4) inhibitor with IC50 of 0.026 nM. |
| PC-60651 |
AMG 580
PDE10A inhibitor
|
AMG 580 (AMG580) is a novel potent, selective phosphodiesterase 10A (PDE10A) inhibitor with IC50 of 0.13 nM. |
| PC-60564 |
PF 05180999
PDE2A inhibitor
|
PF-05180999 (PF 5180999) is a potent, selective, brain-penetrating and orally bioavailable phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 1 nM. |
| PC-60563 |
TAK-915
PDE2A inhibitor
|
TAK-915 (TAK915) is a highly potent, selective, brain-penetrating and orally active phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 0.61 nM. |
| PC-60496 |
AMG-579
PDE10A inhibitor
|
AMG-579 (AMG579) is a potent, selective, CNS penetrant, orally bioavailable PDE10A inhibitor with IC50 of 0.1 nM. |
| PC-60220 |
RPL-554
PDE3/PDE4 inhibitor
|
RPL-554 (Ensifentrine, LS-193855, RPL554) is a potent, orally available, dual PDE3/PDE4 inhibitor with IC50 of 0.4 nM and 1479 nM, respectively. |
| PC-60208 |
BI 409306
PDE9A inhibitor
|
BI 409306 (SUB 166499) is a potent and selective inhibitor of human and rat PDE9A with IC50 of 65 nM and 168 nM, respectively. |
| PC-60205 |
PF-04447943
PDE9A inhibitor
|
PF-04447943 (Edelinontrine) is a potent, selective, brain penetrant, orally active PDE9A inhibitor with IC50 of 8.3 nM. |
| PC-60093 |
PDE5-IN-6c
|
A novel potent, selective PDE5 inhibitor with IC50 of 0.056 nM for PDE5A1. |
