| Cat. No. |
Product Name |
Information |
| PC-20129 |
JZP-430
ABHD6 inhibitor
|
JZP-430 (JZP430) is potent, selective and irreversible inhibitor of α/β-hydrolase domain 6 (ABHD6) with IC50 of 44 nM (hABHD6), 230-fold selectivity over FAAH and lysosomal acid lipase (LAL). |
| PC-20128 |
UCM710
FAAH-ABHD6 inhibitor
|
UCM710 (Glycidyl Palmitoleate, UCM 710) is a potent, dual inhibitor of FAAH and ABHD6, inhibits both AEA and 2-AG hydrolysis in neuron homogenates with IC50 of 1.2 and 0.4 uM respectively, without significantly affecting MAGL activity. |
| PC-20125 |
Orlistat
Lipase inhibitor
|
Orlistat ((–)-Tetrahydrolipstatin, Ro-18-0647) is a small molecule inhibitor of pancreatic and gastric lipase, inhibits DAGLα, DAGLβ, ABHD12, ABHD16A, and platelet-activating factor acetylhydrolase (PAF-AH) with IC50 of 0.06, 0.1, 0.08, 0.03, and 0.05 µM, respectively. |
| PC-38483 |
YM26734
sPLA2 inhibitor
|
YM-26734 is a potent, selective and competitive inhibitor of extracellular group II phospholipase A2 (sPLA2) with IC50 of 85 nM (rabbit platelet-derived group II), >70-fold selectivity over group I PLA2. |
| PC-36138 |
FKGK18
|
FKGK18 (FKGK18) is a potent, selective inhibitor of iPLA2 (group VIA Ca2+-independent phospholipase A2) with IC50 of 50 nM. |
| PC-36137 |
GK563
|
GK563 (GK-563) is a potent, selective inhibitor of Ca2+-independent phospholipase A2 (GVIA iPLA2) with IC50 of 1 nM, >20,000-fold selectivity over GIVA cPLA2. |
| PC-36093 |
IS-741
|
IS-741 (Fuzapladib, IS741) is a synthetic anti-inflammatory agent that shows inhibitory effect on cytosolic phospholipase A2 (cPLA2).. |
| PC-35307 |
sPLA2-X inhibitor 31
|
sPLA2-X inhibitor 31 is a potent, selective secreted phospholipase A2 type X (sPLA2-X) with IC50 of 26 nM, displays 12-fold and 80-fold selectivity over sPLA2-Iia and sPLA2-V, respectively. |
| PC-43510 |
Varespladib
|
Varespladib (LY315920, A-002) is a potent, selective inhibitor of recombinant human, group IIA, nonpancreatic secretory PLA2 (sPLA2) with IC50 of 9 nM, 40-fold less active against group IB, pancreatic sPLA2 and inactive against cytosolic PLA2. |
| PC-63287 |
Edelfosine
|
Edelfosine is a synthetic lysophospholipid analog that selectively inhibits PLC with IC50 of 9.6 uM in fibroblasts and adenocarcinoma cells. |
| PC-43220 |
FIPI
|
FIPI (5-Fluoro-2-indolyl deschlorohalopemide) is a potent, in vivo active phospholipase D (PLD) inhibitor with IC50 of 25 nM for both PLD1 and PLD2. |
| PC-63003 |
SB-435495
|
SB-435495 is a potent, orally active inhibitor of Lp-PLA2 with IC50 of 0.06 nM. |
