| Cat. No. |
Product Name |
Information |
| PC-49075 |
SLP9101555
SphK2 inhibitor
|
SLP9101555 is a potent, selective sphingosine kinase SphK2 with Ki of 90 nM (hSphK2), 200-fold selectivity over SphK1. |
| PC-35528 |
PF-543
SphK1 inhibitor
|
PF-543 (PF543) is a potent, specific, cell-permeant inhibitor of SphK1 with Ki of 3.6 nM, displays >100-fold selectivity over the SphK2 isoform. |
| PC-61768 |
SKI-178
|
SKI-178 is a potent, specific, non-lipid SphK1 inhibitor with Ki of 1.33 uM, displays no significant activity for SphK2 (IC50>25 uM). |
| PC-60525 |
ABC 294640 hydrochloride
SphK2 inhibitor
|
ABC 294640 (ABC294640, Opaganib) is a is a selective, competitive and orally bioavailable sphingosine kinase-2 (SphK-2) inhibitor with IC50 of 60 uM, Ki of 9.8 uM. |
| PC-60524 |
Opaganib
SphK2 inhibitor
|
Opaganib (ABC-294640, ABC294640) is a selective, competitive and orally bioavailable sphingosine kinase-2 (SphK-2) inhibitor with IC50 of 60 uM, Ki of 9.8 uM. |
| PC-49708 |
HWG-35D
SphK2 inhibitor
|
HWG-35D is a potent, selective sphingosine kinase 2 (SphK2, SK2) with IC50 of 41 nM, 100-fold selectivity for SK2 over SK1. |
| PC-49707 |
SLM6071469
SphK2 inhibitor
|
SLM6071469 (SLM 6071469) is a potent, highly selective sphingosine kinase 2 (Sphk2) inhibitor with Ki value of 89 nM (hSphk2), 73-fold selectivity over hSphk1. |
| PC-49706 |
SLM6031434
SphK2 inhibitor
|
SLM6031434 (SLM 6031434) is a potent, highly selective sphingosine kinase 2 (Sphk2) inhibitor with Ki value of 340 nM (hSphk2), 23-fold selectivity over hSphk1. |
| PC-49431 |
K6PC-5
SphK1 activator
|
K6PC-5 is a synthetic ceramide derivative, selective and direct sphingosine kinase 1 (SphK1) activator. |
| PC-47034 |
SLL3071511
CHIKV inhibitor
|
SLL3071511 is a novel potent inhibitor of Chikungunya virus (CHIKV) infection with EC50 of 2.91 uM, inhibits sphingosine kinase SK1 and SK2 with Ki values of 0.27 and 0.66 uM, respectively. |
| PC-35529 |
RB-005
|
RB-005 (RB-005) is a potent, selective inhibitor of sphingosine kinase SphK1 (SK1) with IC50 of 3.6 uM, displays 15-fold selectivity over SphK2.. |
| PC-42821 |
Fingolimod hydrochloride
|
Fingolimod (FTY 720) is an immunomodulatory agent can be phosphorylated by SphK, then functions as a potent agonist of S1P receptors (S1P1/3/4/5) with EC50 of 0.3-5 nM. |
