| Cat. No. |
Product Name |
Information |
| PC-43407 |
LY2157299
TGF-βRI inhibitor
|
LY2157299 (Galunisertib) is a potent, specific inhibitor of TGF-β receptor I kinase ((TGF-βRI) with IC50 of 56 nM. |
| PC-42940 |
K02288
BMP receptor inhibitor
|
K02288 is a potent, selective inhibitor of BMP signaling with IC50 of 1.8/1.1/34.4/6.3 nM for ALK/1/2/3/6, displays 300-fold selectivity for ALK2 over the TGF-β receptor ALK5 and ALK4. |
| PC-42858 |
SB 525334
ALK5 inhibitor
|
SB 525334 is a potent and selective inhibitor of TGF-β1 receptor (ALK5) inhibitor with IC50 of 14,5 nM, 4-fold less potent against ALK4 and inactive for ALK2, ALK3, and ALK6 (IC50>10 uM). |
| PC-63129 |
LY 3200882
ALK5 inhibitor
|
LY 3200882 (LY3200882) is a novel potent, highly selective, ATP competitive TGF-β receptor type 1 (TGFβRI, ALK5) inhibitor. |
| PC-61455 |
TASP0382088
ALK5 inhibitor
|
A potent, selective ALK5 inhibitor with IC50 of 4.8 nM, >100-fold selectivity over 95 different kinases. |
| PC-61454 |
TP-0427736
ALK5 inhibitor
|
TP-0427736 (TP0427736) is a novel potent and selective ALK5 inhibitor with IC50 of 2.72 nM, displays 300-fold selecitvity over ALK3. |
| PC-61447 |
IN-1233
ALK5 inhibitor
|
IN-1233 is a potent and selective TGF-βRI (ALK5) inhibitor with IC50 of 34 nM, prevents tissue hyperplasia in the rat urethra or common iliac artery. |
| PC-61446 |
EW-7195
ALK5 inhibitor
|
A novel potent and selective TGF-βRI (ALK5) inhibitor with IC50 of 4.83 nM, dispalys >300-fold selectivity over p38α. |
| PC-60916 |
San78-130
ALK1 inhibitor
|
San78-130 is a potent, selective activin receptor-like Kinase 1 (ALK1) inhibitor with IC50 of 62 nM, with greater selectivity compared with L-783277. |
| PC-60915 |
L-783277
ALK1 inhibitor
|
L-783277 is a resorcylic lactone type covalent kinase inhibitor that inhibits ALK1 with IC50 of 125 nM, also inhibits FLT3, VEGFR2, VEGFR3, MEK2 with IC50 of 1-10 nM. |
| PC-60770 |
VU 0469381
ALK2 inhibitor
|
VU 0469381 (ML347) is a potent, sellective BMP receptor ALK2 antaognist with Ki of 32 nM, with no affinity for ALK3/4/5/6. |
| PC-60769 |
VU 0465350
ALK3 inhibitor
|
VU 0465350 is a potent, specific BMP receptor activin receptor-like kinase 3 (ALK3) antaognist with Ki of 92.3 nM. |
