| Cat. No. |
Product Name |
Information |
| PC-38423 |
Timtraxanib
VEGFR-2 inhibitor
|
Timtraxanib (AVI 3207) is a peptide mimetic acting as a selective VEGFR-2 inhibitor, inhibits VEGF-2 selectively for curing senile macular degeneration. |
| PC-73181 |
SAR131675
VEGFR3 inhibitor
|
SAR131675 is a potent and selective VEGFR3 inhibitor with IC50 of 23 nM. |
| PC-35130 |
EG00229 free base
|
EG00229 is a specific inhibitor of neuropilin-1 (NRP1)/VEGF-A interaction, inhibits the binding of biotinylated VEGFA to NRP1 with IC50 of 8 uM. |
| PC-43506 |
Apatinib
|
Apatinib (YN968D1) is a multitargeted tyrosine kinase inhibitor (TKI) that inhibits VEGFR-2 (Flk-1/KDR, IC50=1 nM), RET, c-Kit and c-Src (IC50=13, 429 and 530 nM respectively). |
| PC-63493 |
CEP-7055
|
CEP-7055 is a potent, orally active, pan inhibitor of VEGFR, CEP-7055 is the dimethylglycine ester prodrug of CEP-5214, which inhibits human VEGFR2/KDR kinase, VEGFR1/FLT-1 kinase, and VEGFR3/FLT-4 kinase with IC50 of 18 nM, 12 nM, and 17 nM. |
| PC-63212 |
XL-999
|
XL-999 is a potent, multi-targeted receptor tyrosine kinases (RTKs) inhibitor with IC50 of 2.6, 8.2, 1.5 and 0.8 nM for VEGFR-2, FGFR-1, PDGFRβ and FLT-3, respectively. |
| PC-42875 |
KRN-633
|
KRN-633 is a potent, selective VEGFR-2 inhibitor that inhibist the phosphorylation of VEGFR-2 with IC50 of 1.16 nM, also inhibits VEGFR-1, c-Kit and PDGFR-β with IC50 of 11.7, 8.01 and 130 nM. |
| PC-42859 |
Cabozantinib (S-malate)
|
Cabozantinib (XL184) is a potent, multi-kinase inhibitor that inhibits VEGFR2, c-Met, Kit, Axl and Flt3 with IC50 of 0.035, 1.3, 4.6, 7 and 11.3 nM, respectively. |
| PC-42853 |
Ki8751
|
Ki8751 is a potent, selective and orally active VEGFR-2 inhibitor that inhibits VEGFR-2 phosphorylation with IC50 of 0.6 nM. |
| PC-42813 |
Nintedanib esylate
|
Nintedanib esylate (BIBF1120 esylate) is a potent triple angiokinase (VEGFR/PDGFR/FGFR) inhibitor with IC50 of 5/38/18/104/5 nM for VEGFR-2/FGFR-1/PDGFRα/VEGFR-1/VEGFR-3, respectively. |
| PC-61860 |
SU 4312
|
SU 4312 (NSC 86429) is a selective, cell-permeable, brain-penetrant inhibitor of VEGFR2 and PDGFR tyrosine kinase with IC50 of 0.8 and 19.4 uM, respectively. |
| PC-61829 |
AAD777
|
AAD777 (NVP-AAD777. |
