| Cat. No. |
Product Name |
Information |
| PC-42762 |
Lenvatinib
VEGFR inhibitor
|
Lenvatinib (E7080) is a multitargeted kinase inhibitor with IC50s of 4/5.2/22/46 nM for VEGFR2/VEGFR3/VEGFR1/FGFR1 in cell free assays. |
| PC-42450 |
Cediranib
VEGFR inhibitor
|
Cediranib (AZD2171) is a highly potent, orally bioavailable, pan-VEGFR inibitor with IC50 of 1, 5, 3 nM for VEGFR1, 2, 3, respectively. |
| PC-42759 |
Tivozanib
|
Tivozanib (AV951) is a highly potent inhibitor of pan-VEGFR with IC50s of 60/6.5/15 nM for VEGFR1/2/3. |
| PC-42534 |
Brivanib
VEGFR2/FGFR1 inhibitor
|
Brivanib (BMS540215) is a potent, dual inhibitor of VEGFR2 and FGFR1 with IC50 of 25 nM and 148 nM respectively. |
| PC-42622 |
SU14813
|
SU14813 is a potent, broad-spectrum RTKs inhibitor with IC50 ranging from 2 to 50 nM for VEGFR-1, VEGFR-2, PDGFRs, KIT, FLT3, and CSF1R/FMS. |
| PC-21859 |
Axitinib
VEGFR inhibitor
|
Axitinib (AG-013736) is a potent, multi-targeted tyrosine kinase inhibitor with IC50 of 0.1, 0.2, 0.1-0.3, 1.6 nM for VEGFR1, VEGFR2, VEGFR3 and PDGFRβ, respectively. |
| PC-21503 |
SYHA1813
CSF1R/VEGFR inhibitor
|
SYHA1813 is a potent dual inhibitor of CSF1R and VEGFR with IC50 of 19.3, 2.8, 0.3, and 4.3 nM for CSF1R, VEGFR1, 2, and 3, respectively. |
| PC-21447 |
NRPa-308
NRP1 inhibitor
|
NRPa-308 is a neuropilin-1 (NRP-1) antagonist, inhibits the VEGF-A165/NRP-1 binding with IC50 of 42 uM, exerts in vitro anti-angiogenic activity. |
| PC-21310 |
NRP1-4
VEGF-A/NRP1 inhibitor
|
NRP1-4 (Neuropilin 1-4) is a highly potent, specific small molecule inhibitor of VEGF-A binding to neuropilin 1 (NRP1) with IC50 of 0.598 nM, reduces calcium and sodium currents through binding to NRP1 and inhibits the effects of VEGF-A. |
| PC-20705 |
COB223
Angiogenesis inhibitor
|
COB223 is a chemical inhibitor of angiogenesis and tumorigenesis, targets the VEGF signaling pathway upstream of Ras, inhibits endothelial cell migration with IC50 of 5 uM. |
| PC-20338 |
EVT801
VEGFR-3 inhibitor
|
EVT801 (EVT 801) is a potent, selective VEGFR-3 inhibitor with biochemical IC50 of 11 nM, inhibits cellular VEGFR-3 autophosphorylation with IC50 of 39 nM. |
| PC-38754 |
VEGFR inhibitor F16
Angiogenesis inhibitor
|
F16 is a novel specific angiogenesis inhibitor, effectively reduces cell proliferation, tube formation, and migration of HUVECs in a concentration-dependent manner by directly inhibiting VEGF binding and subsequent VEGFR-2 phosphorylation. |
