| Cat. No. |
Product Name |
Information |
| PC-38624 |
Altiratinib
MET/TIE-2/VEGFR inhibitor
|
Altiratinib (DCC-2701) is a potent c-MET/TIE-2/VEGFR inhibitor with IC50 of 2.7 nM (MET WT), 8.0 nM (TIE2 kinase) and 9.2 nM (VEGFR2), also potently inhibits oncogenic MET mutations in the switch region (residues 1228, 1230, and 1250) with IC50 range of 0.37-6 nM. |
| PC-38395 |
Gemnelatinib
c-Met inhibitor
|
Gemnelatinib (GST-HG161) is a potent and highly selective, orally bioavailable c-Met inhibitor, displays significant antitumor activity in preclinical models, has the potential to be effective in HCC with active c-Met signaling. |
| PC-38394 |
Fosgonimeton
HGF/MET modulator
|
Fosgonimeton (ATH-1017, ATH-1001 prodrug) is a highly specific, small-molecule positive modulator of the HGF/MET neurotrophic system, is a prodrug that rapidly converts into the active metabolite ATH-1001 in plasma. |
| PC-36035 |
AMG-458
c-Met inhibitor
|
AMG-458 (AMG458) is a potent, selective, orally bioavailable c-Met inhibitor with Ki of 1.2 nM (human c-Met). |
| PC-35732 |
PLB-1001
MET inhibitor
|
PLB-1001 (Bozitinib, PLB1001, CBI-3103, CBT-101) is a potent, highly selective, ATP-competitive, BBB-permeable MET kinase inhibitor, potently inhibits MET activity by 95.1% at 2 uM. |
| PC-43511 |
Capmatinib
c-MET inhibitor
|
Capmatinib (INCB-28060, INC-280) is a highly potent, selective, ATP competitive inhibitor of c-MET kinase with IC50 of 0.13 nM. |
| PC-43478 |
MK-8033 hydrochloride
|
MK-8033 is a potent, specific, dual c-Met/Ron kinases inhibitor with IC50 of 1/7 nM, also potently inhibits oncogenic c-Met activation loop mutants Y1230C, Y1230H and Y1235D with IC50 of 0.6-1.2 nM. |
| PC-43477 |
MK-8033
c-Met/Ron inhibitor
|
MK-8033 is a potent, specific, dual c-Met/Ron kinases inhibitor with IC50 of 1/7 nM, also potently inhibits oncogenic c-Met activation loop mutants Y1230C, Y1230H and Y1235D with IC50 of 0.6-1.2 nM. |
| PC-63402 |
JNJ-38877618
c-Met inhibitor
|
JNJ-38877618 (OMO-1) is a novel potent, highly selective, orally bioavailable c-Met tyrosine kinase inhibitor with Kd of 1.2, 2.1 and 21 nM for WT, M1250T and Y1235D mutants MET, respectively. |
| PC-43372 |
E-7050
c-Met/VEGFR-2 inhibitor
|
E-7050 (Golvatinib) is a potent, dual c-Met and VEGFR-2 tyrosine kinase inhibitor with IC50 of 14 and 16 nM (kinase phosphorylation inhibition). |
| PC-42888 |
BMS 777607
c-Met inhibitor
|
BMS 777607 (ASLAN002) is a potent, selective, orally efficacious inhibitor of Met kinase with IC50 of 3.9 nM, also potently inhibits Ron, Axl, Tyro-3 and Mer (IC50<15 nM), 40-fold selectivity over Lck, VEGFR-2 and TrkA/B. |
| PC-42849 |
AMG-208
c-Met inhibitor
|
AMG-208 is a potent, small-molecule c-Met inhibitor with IC50 of 5.2 nM against wt MET kinase, also inhibits VEGFR2 with IC50 of 112 nM. |
