| Cat. No. |
Product Name |
Information |
| PC-43477 |
MK-8033
c-Met/Ron inhibitor
|
MK-8033 is a potent, specific, dual c-Met/Ron kinases inhibitor with IC50 of 1/7 nM, also potently inhibits oncogenic c-Met activation loop mutants Y1230C, Y1230H and Y1235D with IC50 of 0.6-1.2 nM. |
| PC-63402 |
JNJ-38877618
c-Met inhibitor
|
JNJ-38877618 (OMO-1) is a novel potent, highly selective, orally bioavailable c-Met tyrosine kinase inhibitor with Kd of 1.2, 2.1 and 21 nM for WT, M1250T and Y1235D mutants MET, respectively. |
| PC-43372 |
E-7050
c-Met/VEGFR-2 inhibitor
|
E-7050 (Golvatinib) is a potent, dual c-Met and VEGFR-2 tyrosine kinase inhibitor with IC50 of 14 and 16 nM (kinase phosphorylation inhibition). |
| PC-42888 |
BMS 777607
c-Met inhibitor
|
BMS 777607 (ASLAN002) is a potent, selective, orally efficacious inhibitor of Met kinase with IC50 of 3.9 nM, also potently inhibits Ron, Axl, Tyro-3 and Mer (IC50<15 nM), 40-fold selectivity over Lck, VEGFR-2 and TrkA/B. |
| PC-42849 |
AMG-208
c-Met inhibitor
|
AMG-208 is a potent, small-molecule c-Met inhibitor with IC50 of 5.2 nM against wt MET kinase, also inhibits VEGFR2 with IC50 of 112 nM. |
| PC-42835 |
SGX-523
c-Met inhibitor
|
SGX-523 (SGX523) is a potent, selective ATP-competitive inhibitor of MET receptor tyrosine kinase with IC50 of 4 nM, does not inhibit RON and a panel of kinases. |
| PC-42832 |
PF-04217903
c-Met inhibitor
|
PF-04217903 is a potent, selective, ATP-competitive c-Met kinase inhibitor with Ki of 4.8 nM, inhibits HGF-stimulated tyrosine phosphorylation of wild type c-Met with IC50 of 7.3 nM in cell-based assays. |
| PC-42829 |
SU11274
c-Met inhibitor
|
SU11274 (PKI-SU11274) is a potent, selective, ATP-competitive c-Met kinase inhibitor with IC50 of 20 nM, >50-fold selectivity over Bcr-Abl, JAK2, PDGFβR. |
| PC-42814 |
PHA-665752
c-Met inhibitor
|
PHA-665752 is a potent, selective, ATP-competitive c-Met inhibitor with Ki/IC50 of 4/9 nM, inhibits c-Met RTK autophosphorylation in A549 cells with IC50 of 45 nM. |
| PC-60656 |
SOMG-833
c-Met inhibitor
|
SOMG833 (Zgwatinib) is a potent, selective, ATP-competitive c-MET inhibitor with IC50 of 0.93 nM. |
| PC-60463 |
SAR 125844
c-Met inhibitor
|
SAR 125844 is a potent, highly selective, ATP-competitive MET receptor tyrosine kinase inhibitor with IC50 of 4.2 nM. |
| PC-70080 |
Glesatinib
AXL/c-Met inhibitor
|
Glesatinib (MGCD-265) is a tyrosine kinase inhibitor that potently and selectively inhibits Met and Axl kinase. |
