| Cat. No. |
Product Name |
Information |
| PC-49312 |
CHF-6366
|
CHF-6366 is a novel potent muscarinic antagonist and β2 agonist (MABA) with pKi of 10.2 and 11.4, respectively. |
| PC-49070 |
VU0405645
M1 Receptor PAM
|
VU0405645 is a potent, biased M1 receptor-positive allosteric modulator, potentiates Ca2+ mobilization in CHO cells stably expressing the M1 receptor with EC50 of 340 nM. |
| PC-38388 |
Emraclidine
M4 mAChR PAM
|
Emraclidine (CVL-231) is a potent, selective positive allosteric modulator (PAM) of M4 muscarinic receptor subtype in development for schizophrenia. |
| PC-73364 |
VU6019650
M5 mAChR antagonist
|
VU6019650 is a potent, highly selective M5 mAChR orthosteric antagonist with IC50 of 36 nM, >100-fold selectivity against human M1-4. |
| PC-72979 |
AZD8871
M3 β2 (MABA)
|
AZD8871 (AZD-8871, Navafenterol) is a potent, selective, and long-lasting M3-antagonist/β2-agonist (MABA) with pIC50 9.5 for human M3 receptor, pEC50 9.5 for β2-adrenoceptor. |
| PC-72662 |
VU6015241
mAChR4 antagonist
|
VU6015241 (VU 6015241) is a highly potent and selective antagonist of M4 muscarinic acetylcholine receptor (mAChR4) with IC50 of 71 nM. |
| PC-72655 |
HTL9936
M1 agonist
|
HTL9936 (HTL-9936) is a potent, selective M1-muscarinic acetylcholine (M1) receptor partial agonist with EC50 of 32 nM. |
| PC-72280 |
ASP8302
M3 PAM
|
ASP8302 (ASP 8302) is a potent, selective, positive allosteric modulator (PAM) of muscarinic M3 receptor. |
| PC-35837 |
AZD6088
mAChR M1 agonist
|
AZD6088 (AZD-6088) is a potent and selective, orally bioavailable partial agonist of the M1 muscarinic receptor, reduces heat hyperalgesia in SNL rats with an EC50 of 46.6 nM.. |
| PC-35478 |
VU0453595
M1 PAM
|
VU0453595 (VU453595) is a potent, selective M1 positive allosteric modulator (PAM) with EC50 of 3.2 uM (rM1). |
| PC-61043 |
Revefenacin
|
Revefenacin (TD4208, GSK 1160724) is a novel potent, long-acting, lung-selective inhaled muscarinic antagonist that has high affinity at M3 receptor, demonstrates in vitro kinetic selectivity for M3 over M2 and no meaningful off-target activity. |
| PC-60736 |
VU 0255035
|
VU 0255035 is a potent, selective, CNS penetrant and competitive orthosteric antagonist of M1 mAChR with IC50 of 132 nM, >75-fold selectivity over M2-M5. |
