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Cat. No. Product Name Information
PC-72730

RTICBM-189

CB1 NAM

RTICBM-189 is a potent, selective, brain-penetrant CB1 negative allosteric modulator (NAM) with pIC50 of 7.54 in Ca2+ assay, 5.29 in GTPγS assay.
PC-72729

RTICBM-229

CB1 NAM

RTICBM-229 is a potent, selective, brain-penetrant CB1 negative allosteric modulator (NAM) with IC50 of 169 nM in Ca2+ assay, 40 nM in GTPγS assay.
PC-72728

RTICBM-74

CB1 NAM

RTICBM-74 is a potent, selective, brain-penetrant CB1 negative allosteric modulator (NAM) with IC50 of 23 nM in Ca2+ assays.
PC-35625

XL-001

CB2 inverse agonist

XL-001 (XL001) is a novel specific CB2 inverse agonist with Ki of 0.5 nM.
PC-35592

AM9405

CB1/5-HT3 agonist

AM9405 (AM-9405, GAT-379) is novel potent, peripherally active cannabinoid type 1 (CB1) and 5-HT3 receptor agonist, inhibits the EFS-induced twitch contraction of the ileum and the colon with IC50 of 0.076 and 45.71 nM, respectively.
PC-35536

VCE-004.3

PPARγ/CB2 agonist

VCE-004.3 (VCE004.3) is a novel semi-synthetic cannabidiol derivative behaving as a dual PPARγ/CB2 agonist and CB1 receptor modulator, binds and activates PPARγ (IC50=3.5 uM) and CB2 receptors (pKi=6.69) and antagonizes CB1 receptor (pKi=5.61).
PC-35488

GAT100

CB1R modulator

GAT-100 (GAT100) is a potent, selective CB1R negative allosteric modulator (NAM) with cAMP EC50 and β-arr EC50 of 174 nM and 2.1 nM, does not exhibit inverse agonism.
PC-35485

GAT211

CB1R modulator

GAT-211 (GAT211) is a selective cannabinoid 1 receptor (CB1R) positive allosteric modulator with pKb of 7.26, Arrestin2 EC50 of 775 nM.
PC-35125

PrNMI

CB1 agonist

PrNMI is a peripherally restricted cannabinoid 1 receptor (CB1R) agonist with Ki of 1.18 nM and EC50 of 182 nM (hCB1R).
PC-43469

WIN 55,212-2 mesylate

Cannabinoid receptor agonist

WIN 55,212-2 mesylate (WIN 55212-2) is a potent cannabinoid receptor agonist with Ki of 62.3 and 3.3 nM for human recombinant CB1 and CB2 receptors, respectively.
PC-43465

Org 27569

CB1R modulator

Org 27569 is a potent, selective, allosteric modulator of cannabinoid CB1 receptor, significantly increases the binding of the CB1 receptor agonist [3H]CP 55,940 with pKb of 5.67.
PC-43210

DBPR211

CB1 antagonist

DBPR211 (BPRCB1184, CB1-IN-4) is a potent, selective, peripherally restricted cannabinoid-1 (CB1) receptor antagonist with Ki of 0.3 nM, EC50 of 3.0 nM.

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