| Cat. No. |
Product Name |
Information |
| PC-23881 |
PAM_16A
TMEM16A PAM
|
PAM_16A is a potent, selective, positive allosteric modulator of TMEM16A (Anoctamin-1, ANO1) with EC50 of 3.6 nM, activates heterologous TMEM16A channels, has no effect on the closely related TMEM16B channel. |
| PC-22007 |
NMD670
ClC-1 inhibitor
|
NMD670 (NMD-670) is a potent, specific and orally bioavailable ClC-1 chloride channel inhibitor with EC50 of 1.6 uM, restores muscle function in rat models of myasthenia gravis (MG). |
| PC-21203 |
OV350
KCC2 activator
|
OV350 (OV-350) is a potent, selective and direct K+-Cl- cotransporter KCC2 agonist with EC50 of 261.4 nM, with no effect on KCC2 plasma membrane accumulation and phosphorylation. |
| PC-20482 |
K786-4469
TMEM16A inhibitor
|
K786-4469 is a small molecule inhibitor of anoctamin 1 (ANO1), suppresses cancer metastasis in vitro and in vivo. |
| PC-20364 |
Ani9
TMEM16A inhibitor
|
Ani9 is a potent, selective anoctamin1 (ANO1, TMEM16A) channel inhibitor with IC50 of 107 nM, with negligible effect on ANO2 (IC50>10 uM). |
| PC-20363 |
CaCCinh-A01
CaCC/TMEM16A inhibitor
|
CaCCinh-A01 is a small molecule Ca(2+)-activated Cl(-) channel (CaCC) inhibitor, inhibits both I(sc) and transepithelial conductance in a concentration-dependent manner (IC50=6.3 uM). |
| PC-49192 |
TMEM16A blocker 1PBC
TMEM16A blocker
|
1PBC is a small molecule blocker of calcium-activated chloride channel TMEM16A, blocks TMEM16A completely with an IC50 of 4 uM at zero mV and saturating Ca2+ concentration (2 uM). |
| PC-47048 |
TMinh-23
TMEM16A inhibitor
|
TMinh-23 is (Compound 10bm) is a potent, selective inhibitor of transmembrane protein 16A (TMEM16A or ANO1, DOG1, ORAOV2, TAOS-2) with IC50 of 30 nM in short-circuit current assays, weakly inhibits TMEM16B (IC50=400 nM, 13 -fold selectivity). |
| PC-38752 |
DRAinh-A270
SLC26A3 inhibitor
|
DRAinh-A270 is a small-molecule, selective inhibitor of intestinal anion exchanger SLC26A3 (DRA), inhibits SLC26A3-mediated chloride/bicarbonate exchange with IC50 of 35 nM and oxalate/chloride exchange with IC50 of 60 nM. |
| PC-38691 |
VI-116
VRAC inhibitor
|
VI-116 is a potent and selective volume-regulated anion channel (VRAC) inhibitor, fully inhibits VRAC-mediated I- quenching with an IC50 of 1.27 uM in LN215 cells. |
| PC-38479 |
MONNA
TMEM16A inhibitor
|
MONNA a potent, selective inhibitor of the TMEM16A calcium-activated chloride channel (Anoctamin-1, ANO1) with IC50 of 80 nM (xANO1). |
| PC-72552 |
CLC-2-IN-AK42
CLC-2 inhibitor
|
CLC-2-IN-AK42 (CLC-2 inhibitor AK42, AK42) is a potent, specific small-molecule inhibitor of voltage-gated chloride channel CLC-2 with IC50 of 17 nM (human CLC-2). |
