| Cat. No. |
Product Name |
Information |
| PC-49351 |
ODM-209
CYP11A1 inhibitor
|
ODM-209 (ODM209) is a potent, selective, orally bioavailable inhibitor of CYP11A1 (cholesterol side-chain cleavage enzyme) with potential antineoplastic activity, inhibits the biosynthesis of pregnenolone. |
| PC-49349 |
ODM-208
CYP11A1 inhibitor
|
ODM-208 (ODM208) is a potent, selective, orally bioavailable CYP11A1 inhibitor, inhibits the biosynthesis of pregnenolone with IC50 of 15 nM in NCI-H295R cells. |
| PC-49301 |
BMS-737
CYP17 lyase inhibitor
|
BMS-737 (BMS737) is a potent, , selective, non-steroidal, reversible inhibitor of CYP17 lyase, 11-fold selectivity for CYP17 lyase over CYP17 hydroxylase. |
| PC-49296 |
BMS-351
CYP17A1 lyase inhibitor
|
BMS-351 (BMS351) is a potent, selective, reversible, nonsteroidal CYP17A1 lyase inhibitor with IC50 of 19 nM. |
| PC-38446 |
Dafadine-A
DAF-9 inhibitor
|
Dafadine-A is a small molecule inhibitor of DAF-9 cytochrome P450, binds DAF-9 and specifically inhibits its enzymatic activity, promotes dauer formation and longevity of Caenorhabditis elegans. |
| PC-72852 |
VID400
CYP24A1 inhibitor
|
VID400 (NVP-VID400, SDZ285-428) is a potent, selective inhibitor of CYP24A1. |
| PC-63002 |
YM116
|
YM116 is a potent CYP17A1 (17,20-lyase) inhibitor with IC50 with Ki of 0.38 nM, inhibits C17-20 lyase activity in human testicular microsomes with IC50 of 4.2 nM. |
| PC-62248 |
Dafadine A
|
Dafadine A is the first reported small-molecule DAF-9 cytochrome P450 inhibitor that robustly induces dauer formation in in the nematode Caenorhabditis elegans. |
| PC-62112 |
ML368
|
ML368 (SR 9186) is a potent, selective cytochrome P450 enzyme CYP3A4 inhibitor with IC50 of 4 nM (convert testosterone to hydroxytestosterone), displays >2,000-fold selectivity over CYP3A5.. |
| PC-61908 |
N1-hexyl-N5-benzyl-biguanide mesylate
|
N1-hexyl-N5-benzyl-biguanide mesylate (HBB) is a potent and specific inhibitor of CYP3A4 AA epoxygenase activity with IC50 of 9.5 uM for inhibition of CYP3A4-mediated (±)-14,15-EET synthesis. |
| PC-61747 |
LKY-047
|
LKY-047 is a decursin derivative that potently and selectively inhibits CYP2J2, competitively inhibits CYP2J2-mediated astemizole O-demethylase and terfenadine hydroxylase activity with Ki of 0.96 and 2.61 uM, respectively. |
| PC-61692 |
CYP11B1-IN-25
|
CYP11B1-IN-25 is a selective, potent 11β-hydroxylase (CYP11B1) inhibitor with IC50 of 2 nM, displays 14-fold selectivity over CYP11B2. |
