| Cat. No. |
Product Name |
Information |
| PC-45788 |
Methoxsalen
CYP2A5/CYP2A6 inhibitor
|
Methoxsalen (8-Methoxypsoralen, Xanthotoxin, 8-MOP) is a potent tricyclic furocoumarin suicide that used to treat psoriasis, eczema, vitiligo and some cutaneous lymphomas in conjunction with exposing the skin to sunlight. |
| PC-45614 |
CYP1B1 inhibitor TMS
CYP1B1 inhibitor
|
TMS is a potent and selective inhibitor of the EROD activity of P450 1B1 (CYP1B1) with IC50 of 6 nM |
| PC-45937 |
Abiraterone
CYP17A1 inhibitor
|
Abiraterone (CB-7598) is a potent and irreversible CYP17A1 inhibitor with IC50 of 4 nM for 17α-hydroxylase. |
| PC-45958 |
Abiraterone acetate
CYP17A1 inhibitor
|
Abiraterone acetate (CB-7598) is a potent and irreversible CYP17A1 inhibitor with IC50 of 4 nM for 17α-hydroxylase. |
| PC-45936 |
TOK-001
CYP17 inhibitor
|
TOK-001 (Galeterone) is a potent 17α-hydroxylase/17,20-lyase (CYP17) inhibitor with IC50 of 300 nM. |
| PC-42617 |
Cobicistat
CYP3A inhibitor
|
Cobicistat (GS-9350) is a pharmacoenhancer that acts as potent and selective inhibitor of human CYP3A with IC50 of 30-285 nM. |
| PC-45969 |
Bergaptol
CYP3A4 inhibitor
|
Bergaptol is a natural furanocoumarin that is found to be a potent inhibitor of debenzylation activity of CYP3A4 enzyme with IC50 of 24.92 uM. |
| PC-42626 |
Orteronel
CYP17A1 inhibitor
|
Orteronel (TAK-700) is a highly selective CYP17A1 (17,20-lyase) inhibitor with IC50 of 17 nM for human 17,20-lyase. |
| PC-24523 |
17-ODYA
CYP450 inhibitor
|
17-ODYA (17-octadecynoic acid) is a CYP450 omega-hydroxylase ( CYP450 ω) inhibitor CYP450 ω-hydroxylase inhibitor, also inhibits the formation of 20-hydroxyeicosatetraenoic acid (20-HETE), epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids by rat renal cortical microsomes incubated with arachidonic acid. |
| PC-24474 |
Lorundrostat
Aldosterone synthase inhibitor
|
Lorundrostat (MT-4129) is a highly selective inhibitor of CYP11B2 (aldosterone synthase) Ki values of 1.27 nM for hCYP11B2 and 475 nM for hCYP11B1, reduces systolic blood pressure. |
| PC-24397 |
SCM-08
CYP3A4 inhibitor
|
SCM-08 is a potent, selective, non-suicide CYP3A4 inhibitor with IC50 of 0.43 uM in P450-Glo inhibition assays, 47-fold selecitve over CYP3A5. |
| PC-24396 |
SCM-18
CYP3A4 inhibitor
|
SCM-18 is a potent, highly selective, non-suicide CYP3A4 inhibitor with IC50 of 0.36 uM, has >170 fold selectivity over CYP3A5 (IC50>60 uM). |
