| Cat. No. |
Product Name |
Information |
| PC-28058 |
Metyrapone
11β-hydroxylase inhibitor
|
Metyrapone (Su-4885, NSC-25265) is a potent and orally active 11β-hydroxylase (CYP11B1) inhibitor and autophagy activator, also inhibits the production of aldosterone, inhibits synthesis of endogenous adrenal corticosteroid, decreases glucocorticoid levels, and also affects behavior and emotion in vivo. |
| PC-27980 |
BM-51
CYP4Z1 inhibitor
|
BM-51 is a potent, specific inhibitor of cytochrome P450 enzyme CYP4Z1 with IC50 of 91.7 nM, shows high selectivity against CYP4 isozymes (>100 folds). |
| PC-27657 |
Bergamottin
CYP1A1 inhibitor
|
Bergamottin (5-Geranoxypsoralen, Bergamotine) is a bioactive component of bergamot and a competitive inhibitor of cytochrome P450 1A1 (CYP1A1) with Ki of 10.7 nM. |
| PC-25060 |
Seviteronel
CYP17A1 inhibitor
|
Seviteronel (VT-464) is a potent, selective and oral inhibitor of CYP17A1 inhibitor with 17,20-lyase IC50 of 69 nM, 10-fold selective over 17α-hydroxylase. |
| PC-25058 |
CFG920
CYP17A1 inhibitor
|
CFG920 (Lapiteronel) is a potent, selective cytochrome P450c17 (CYP17A1) inhibitor. |
| PC-24474 |
Lorundrostat
Aldosterone synthase inhibitor
|
Lorundrostat (MT-4129) is a highly selective inhibitor of CYP11B2 (aldosterone synthase) Ki values of 1.27 nM for hCYP11B2 and 475 nM for hCYP11B1, reduces systolic blood pressure. |
| PC-24395 |
SCM-01
CYP3A4 inhibitor
|
SCM-01 is a potent, selective, non-suicide CYP3A4 inhibitor with IC50 of 0.32 uM in P450-Glo inhibition assays, 14-fold selecitve over CYP3A5. |
| PC-24049 |
Vicadrostat
Aldosterone synthase inhibitor
|
Vicadrostat (BI 690517) is a potent, highly selective aldosterone synthase (AS) inhibitor with IC50 of 48 nM, 250-fold selectivity for aldosterone synthase compared with cortisol synthase. |
| PC-23802 |
CYP3cide
CYP3A4 inhibitor
|
CYP3cide (PF-04981517) is a potent, efficient, and specific time-dependent inhibitor of cytochrome P4503A4 (CYP3A4) with IC50 of 0.03 uM, >500-fold selective over CYP3A5 and CYP3A7. |
| PC-20618 |
Decursin
CYP2J2 inhibitor
|
Decursin ((+)-Decursin) is a potent anti-tumor agent and a potent protein kinase C activator, induces apoptosis and cell cycle arrest at G1 phase. |
| PC-20617 |
LKY-047
CYP2J2 inhibitor
|
LKY-047 (LKY047) is a potent, highly selective and reversible competitive cytochrome P450 CYP2J2 (CYP2J2) inhibitor with IC50 of 1.7 uM. |
| PC-49351 |
ODM-209
CYP11A1 inhibitor
|
ODM-209 (ODM209) is a potent, selective, orally bioavailable inhibitor of CYP11A1 (cholesterol side-chain cleavage enzyme) with potential antineoplastic activity, inhibits the biosynthesis of pregnenolone. |
