| Cat. No. |
Product Name |
Information |
| PC-24637 |
Metopimazine mesylate
D2R antagonist
|
Metopimazine mesylate (NG101) is a selective, peripherally restricted dopamine D2 receptor (D2R) antagonist, has potential for the symptomatic treatment of nausea and vomiting and chemotherapy-induced nausea and vomiting. |
| PC-24332 |
ESG-1-61
D3 receptor antagonist
|
ESG-1-61 is a potent, selective antagonist/inverse agonist of dopamine D3 receptor (D3R) with Ki of 0.73 nM, EC50 of 3.36 nM (Go activation) and4.36 nM (β-arrestin2 recruitment), show ~20-fold binding selectivity for D3 over D2 receptors. |
| PC-24331 |
ESG-1-60
D3 receptor agonist
|
ESG-1-60 is a potent, selective partial agonist of dopamine D3 receptor (D3R) with Ki of 0.14 nM, EC50 of 3.43 nM (Go activation) and 0.2 nM (β-arrestin2 recruitment), show ~20-fold binding selectivity for D3 over D2 receptors. |
| PC-24330 |
Cariprazine hydrochloride
D3 receptor agonist
|
Cariprazine (RGH-188) hydrochloride is an antipsychotic compound that exhibits high affinity for the D3 (Ki=0.085 nM) and D2 (Ki=0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (Ki=2.6 nM). |
| PC-24329 |
Cariprazine
D3 receptor agonist
|
Cariprazine (RGH-188) is an antipsychotic compound that exhibits high affinity for the D3 (Ki=0.085 nM) and D2 (Ki=0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (Ki=2.6 nM). |
| PC-23683 |
Eticlopride hydrochloride
D2R antagonist
|
Eticlopride hydrochloride is a selective dopamine D2‐like receptor (D2R) antagonist with Ki of 0.09 nM, shows little to no affinity for α1‐adrenergic, α2‐adrenergic, 5HT1, 5HT2 receptors, exerts antipsychotic activities. |
| PC-23532 |
Fenoldopam mesylate
Dopamine D1 agonist
|
Fenoldopam (SKF82526) is a potent, selective dopamine-1 (DA-1) receptor partial agonist with EC50 of 55.5 nM in stimulating cAMP accumulation in LLC-PK1 cells. |
| PC-23210 |
Amisulpride
D(2/3)/5-HT(7) inhibitor
|
Amisulpride (SEP-4199, DAN2163) is an N-methylated analogue of amisulpride, selective dopamine D(2/3)/5-HT(7) inhibitor, binds to the D2 receptor and 5-HT7 receptor with Ki of 1.1 nM and 44 nM respectively, shows potential for treatment of schizophrenia and other psychiatric disorders. |
| PC-23209 |
LB-102
D(2/3)/5-HT(7) inhibitor
|
LB-102 is an N-methylated analogue of amisulpride, selective dopamine D(2/3)/5-HT(7) inhibitor, binds to the D2 receptor and 5-HT7 receptor with Ki of 0.85 nM and 31 nM respectively, shows potential for treatment of schizophrenia and other psychiatric disorders. |
| PC-23120 |
SB-277011 hydrochloride
D3R antagonist
|
SB-277011 hydrochloride (SB277011A) is a potent and selective dopamine D3 receptor antagonist with pKi of 8.0. |
| PC-23118 |
FOB02-04A
D3R agonist
|
FOB02-04A is a selective, bitopic and full agonist of dopamine 3 receptor (D3R) with Ki of 1.85 nM, 47- and 155-fold selective over D2R and D4R. |
| PC-23109 |
D5R agonist 5j
D5R agonist
|
D5R agonist 5j is a selective dopamine D5 receptor (D5R) partial agonist with EC50 of 269.7 nM, not active at the other four dopamine receptors. |
