| Cat. No. |
Product Name |
Information |
| PC-26137 |
ENX-104
D2/D3 receptor antagonist
|
ENX-104 is a highly selective and potent dopamine D2/D3 receptor antagonist with IC50 of 1.1 nM, 0.1 nM, 2.4 nM and 15.3 nM for D2-like inhibitory dopamine receptors D2S, D2L, D3, and D4 respectively. |
| PC-26129 |
Thioridazine
D2R antagonist
|
Thioridazine is a selective antagonist of dopamine receptor D2 family proteins, exhibits potent anti-psychotic and anti-anxiety activities. |
| PC-26051 |
7-OH-DPAT
D3 dopamine receptor agonist
|
7-OH-DPAT (7-Hydroxy-DPAT) is a selective D3 dopamine receptor (D3R) agonist, exhibits significant pharmacological activity in modulating locomotor behavior and dopamine metabolism within the brain. |
| PC-25355 |
D-583
D2/D3 agonist
|
D-583 is a potent hybrid D2/D3 agonist and iron (II)-specific chelator with EC50 of 3.14 nM (Emax=63%) and 0.62 nM (Emax=68%) for D2 and D3 receptors respectively, exhibits anti-ferroptotic activity. |
| PC-25209 |
YQA14
D3R antagonist
|
YQA14 is a potent, selective D3 dopamine receptor (D3R) antagonist with Ki of 0.68 nM, shows no affinity for D2R. |
| PC-25208 |
SR 21502
D3R antagonist
|
SR 21502 is a potent, selective D3 dopamine receptor (D3R) antagonist with Ki of 4.2 nM, >120-fold binding selectivity over D2 receptor. |
| PC-25085 |
Raxlaprazine etomoxil
D3/D2 receptor modulator
|
Raxlaprazine etomoxil is a potent, selective dopamine D3/D2 receptor modulator. |
| PC-24638 |
Metopimazine
D2R antagonist
|
Metopimazine is a selective, peripherally restricted dopamine D2 receptor (D2R) antagonist, has potential for the symptomatic treatment of nausea and vomiting and chemotherapy-induced nausea and vomiting. |
| PC-24637 |
Metopimazine mesylate
D2R antagonist
|
Metopimazine mesylate (NG101) is a selective, peripherally restricted dopamine D2 receptor (D2R) antagonist, has potential for the symptomatic treatment of nausea and vomiting and chemotherapy-induced nausea and vomiting. |
| PC-24332 |
ESG-1-61
D3 receptor antagonist
|
ESG-1-61 is a potent, selective antagonist/inverse agonist of dopamine D3 receptor (D3R) with Ki of 0.73 nM, EC50 of 3.36 nM (Go activation) and4.36 nM (β-arrestin2 recruitment), show ~20-fold binding selectivity for D3 over D2 receptors. |
| PC-24331 |
ESG-1-60
D3 receptor agonist
|
ESG-1-60 is a potent, selective partial agonist of dopamine D3 receptor (D3R) with Ki of 0.14 nM, EC50 of 3.43 nM (Go activation) and 0.2 nM (β-arrestin2 recruitment), show ~20-fold binding selectivity for D3 over D2 receptors. |
| PC-24330 |
Cariprazine hydrochloride
D3 receptor agonist
|
Cariprazine (RGH-188) hydrochloride is an antipsychotic compound that exhibits high affinity for the D3 (Ki=0.085 nM) and D2 (Ki=0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (Ki=2.6 nM). |
