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Cat. No. Product Name Information
PC-72737

Belzutifan

HIF2α inhibitor

Belzutifan (PT2977, MK-6482) is a potent and selective small-molecule inhibitor of HIF2α with SPA IC50 of 9 nM, EC50 of 11 nM (HIF-2α luciferase assay).
PC-72705

KUSC-5037

HIF-1 inhibitor

KUSC-5037 (KUSC5037) is a novel effective HIF-1 inhibitor with IC50 of 1.2 uM against HIF-1 transcriptional activity.
PC-38083

Izilendustat

HIF-PHD inhibitor

Izilendustat is a potent inhibitor of HIF prolyl hydroxylase (PHD) which stabilizes hypoxia inducible factor- 1 alpha (HIF- lα), as well as hypoxia inducible factor-2 (HIF-2)..
PC-43531

Roxadustat

HIF-PHD inhibitor

Roxadustat (FG4592, FG-4592) is a potent, orally available HIF prolyl hydroxylase (HIF-PHD) with IC50 of 591.4 nM.
PC-43140

Molidustat

HIF-PHD inhibitor

Molidustat (BAY 85-3934) is an orally active small molecule inhibitor of hypoxia inducible factor prolyl hydroxylase (HIF-PHD) with IC50 of 480 nM, 280 nM and 450 nM for PHD1, PHD2, and PHD3, respectively.
PC-62044

KHS-101

KHS-101 (KHS101) is a small molecule that selectively induces a neuronal differentiation phenotype, induces neuronal differentiation in cultured hippocampal neural progenitor cells (NPCs) by interacting with TACC3 (EC50=1 uM).
PC-61213

JNJ-42905343

JNJ-42905343 is a potent, selective, orally active prolyl hydroxylase (PHD) inhibitor with pKi of 8.07, 7.48 and 7.27 for PHD1, PHD2 and PHD3 respectively.
PC-60509

Desidustat

Desidustat (ZYAN1) is a novel HIF prolyl hydroxylase (PHD) inhibitor under clinical development for the treatment of anemia.
PC-60370

IDF-11774

HIF-1α inhibitor

IDF-11774 (IDF 11774, IDF11774) is a potent, orally bioavailable HIF-1 inhibitor that reduces the HRE-luciferase activity of HIF-1α (IC50=3.65 uM) and blocks HIF-1α accumulation under hypoxia in HCT116 human colon cancer cells.
PC-60317

PT-2399

PT-2399 (PT 2399, PT2399) is a selective, potent HIF-2α antagonist that binds directly to the HIF2α PAS B domain.
PC-60148

JTZ-951 hydrochloride

HIF-PHD inhibitor

Enarodustat hydrochloride (JTZ-951 hydrochloride) is a novel potent, orally active HIF prolyl hydroxylase (PHD) inhibitor with IC50 of 0.22 uM for PHD2.
PC-60147

JTZ-951

HIF-PHD inhibitor

Enarodustat (JTZ-951) is a novel potent, orally active HIF prolyl hydroxylase (PHD) inhibitor with IC50 of 0.22 uM for PHD2.

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